A decreased serum concentration of nitrite/nitrate correlates with an increased plasma concentration of lactate during and after major surgery
| Autor: | Susumu Fujioka, Kazuo Okada, Kiyoshi Mizumoto |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Surgical stress Nitric Oxide Nitric oxide chemistry.chemical_compound Nitrate Stress Physiological medicine Humans Lactic Acid Nitrite Digestive System Surgical Procedures Nitrites Aged Morning Postoperative Care Nitrates Interleukin-6 business.industry Interleukin General Medicine Middle Aged Thoracic Surgical Procedures Surgery Point of delivery chemistry Female business Perfusion |
| Zdroj: | Surgery Today. 30:871-874 |
| ISSN: | 1436-2813 0941-1291 |
| DOI: | 10.1007/s005950070036 |
| Popis: | A decrease in the production of nitric oxide (NO) due to surgical stress has been reported. We investigated whether this decrease in NO production was related to cytokine induction and/or other clinical parameters. We therefore measured the concentrations of serum nitrite/nitrate (a stable end product of NO), serum interleukin (IL)-6, and standard clinical parameters in 13 patients undergoing major upper abdominal and thoracoabdominal surgery at preanesthesia (PRE), 2h after a surgical incision (2H), at the end of surgery (END), and on the morning of postoperative days 1 (POD 1) and 3 (POD 3). The serum concentration of nitrite/nitrate was thus found to have significantly decreased at END, POD 1, and POD 3 compared with PRE. In addition, the serum nitrite/nitrate concentration correlated negatively with the plasma lactate level, and no relationship was observed between the serum nitrite/nitrate level and either the serum IL-6 level or any other clinical parameters. Our findings thus suggest that the decrease in the serum nitrite/nitrate level might therefore be related to tissue hypoperfusion both during and after major surgery. |
| Databáze: | OpenAIRE |
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