Dopaminergic and Prefrontal Basis of Learning from Sensory Confidence and Reward Value
| Autor: | Miles J. Wells, Michael S. Okun, Matteo Carandini, Adam Kepecs, Kenneth D. Harris, Armin Lak, Karolina Farrell, Charu Bai Reddy, Harsha Gurnani, Morgane M Moss |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Prefrontal Cortex Sensory system Mice Transgenic Optogenetics Choice Behavior 03 medical and health sciences Mice 0302 clinical medicine Reward Dopamine medicine Psychophysics Reinforcement learning Animals Learning Prefrontal cortex General Neuroscience Dopaminergic Neurons Dopaminergic Mice Inbred C57BL 030104 developmental biology Psychology Neuroscience Value (mathematics) 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Neuron. 105(4) |
| ISSN: | 1097-4199 |
| Popis: | Deciding between stimuli requires combining their learned value with one's sensory confidence. We trained mice in a visual task that probes this combination. Mouse choices reflected not only present confidence and past rewards but also past confidence. Their behavior conformed to a model that combines signal detection with reinforcement learning. In the model, the predicted value of the chosen option is the product of sensory confidence and learned value. We found precise correlates of this variable in the pre-outcome activity of midbrain dopamine neurons and of medial prefrontal cortical neurons. However, only the latter played a causal role: inactivating medial prefrontal cortex before outcome strengthened learning from the outcome. Dopamine neurons played a causal role only after outcome, when they encoded reward prediction errors graded by confidence, influencing subsequent choices. These results reveal neural signals that combine reward value with sensory confidence and guide subsequent learning. |
| Databáze: | OpenAIRE |
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