Formulation of alginate based hydrogel from brown seaweed, Turbinaria conoides for biomedical applications
| Autor: | Kalimuthu Kapilan, Ramachandiran Sivaramakrishnan, Selvaraj Uthra, Shankar Kanchana, Muthuvel Arumugam, Naidu Kavitha, Kumar Mohan, D. Yuvaraj, Thennarasu Padmini Karunya |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Turbinaria conoides 03 medical and health sciences 0302 clinical medicine medicine lcsh:Social sciences (General) lcsh:Science (General) Sodium alginate Multidisciplinary Chemistry Microbead (research) Anticancer drug Materials science Pharmaceutical science Hydrogel 030104 developmental biology Brown seaweed Drug delivery Self-healing hydrogels Materials chemistry lcsh:H1-99 Swelling medicine.symptom Biomedical engineering 030217 neurology & neurosurgery Nuclear chemistry Biotechnology lcsh:Q1-390 |
| Zdroj: | Heliyon, Vol 5, Iss 12, Pp e02916-(2019) |
| ISSN: | 2405-8440 |
| Popis: | Sodium Alginate (SA) is an excellent carrier in various drug delivery systems. In this study, SA was synthesized from brown seaweed, Turbinaria conoides with a yield of 31.3 ± 0.86%. The analysis of physicochemical properties of extracted alginate (ALG) determined its purity. The structural confirmations of ALG were studied through FTIR, XRD and SEM analysis. Formulation of ALG with collagen (COL) as a wound healing microfilm showed potential anti-inflammatory properties (81.3 ± 1.77%) and sustained drug release. Likewise, the ALG microbead encapsulated with an anticancer drug, Tamoxifen indicated an in vitro sustained release in the range of 62 ± 0.70% - 91 ± 0.56%. The overall swelling behavior of both the hydrogels, microfilm and microbead provides new opportunities for development of natural ALG in this therapeutic era. |
| Databáze: | OpenAIRE |
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