Calcium-Channel Blockers and Other Factors Influencing Delayed Function in Renal Allografts
| Autor: | A. N. Hillis, C. J. Ferguson, J. R. Salaman, P.J.A. Griffin, John D. Williams |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
medicine.medical_specialty Nifedipine medicine.medical_treatment Renal function chemistry.chemical_compound medicine Humans Dialysis Retrospective Studies Immunosuppression Therapy Transplantation Creatinine Kidney business.industry Graft Survival Perioperative Calcium Channel Blockers Kidney Transplantation Surgery medicine.anatomical_structure chemistry Nephrology Reperfusion Injury Anesthesia Hemodialysis business medicine.drug |
| Zdroj: | Nephrology Dialysis Transplantation. 5:816-820 |
| ISSN: | 1460-2385 0931-0509 |
| DOI: | 10.1093/ndt/5.9.816 |
| Popis: | A retrospective analysis was undertaken to examine the influence of calcium-channel blocking drugs on early renal allograft function. Delayed function was defined as the need for dialysis or a reduction in serum creatinine of less than 15% within 4 days of transplantation. The drug histories of 172 patients were examined. After exclusions, the data from 138 patients were analysed. No patient was taking any calcium-channel blocking drug other than nifedipine. Thirty-one patients were taking nifedipine at the time of transplantation and these had a delayed function rate of 16% compared with 40% for 107 patients not taking nifedipine (chi 2, P less than 0.05). Delayed function occurred in 61% of cases when the donor age was over 50 years compared with 29% with younger donors (chi 2, P less than 0.05). A total ischaemic time of longer than 24 h and administration of inotropic support to the donor were associated with delayed function (chi 2, P less than 0.05). Administration to the donor of mannitol, steroids, phenoxybenzamine and heparin had no effect on the rate of delayed function. Recipients treated with low-dose dopamine in the perioperative period had no advantage. Elevated trough whole blood concentrations of cyclosporin in the first week after transplant were associated with delayed function (Mann-Whitney U, P less than 0.05). |
| Databáze: | OpenAIRE |
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