Constituents of Polyalthia longifolia var. pendula
| Autor: | Pi-Yu Chen, Mei-Jhen Wang, Ching-Kuo Lee, Tung-Ying Wu, Tzong-Huei Lee, Wu-Che Wen, Fu-Yu Tsai |
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| Rok vydání: | 2009 |
| Předmět: |
Stereochemistry
Carboxylic acid Berberine Alkaloids Polyalthia Taiwan Pharmaceutical Science Pharmacognosy Diterpenes Clerodane Analytical Chemistry chemistry.chemical_compound Drug Discovery Polyalthia longifolia Humans Pharmacology chemistry.chemical_classification Plants Medicinal Molecular Structure Plant Stems biology Alkaloid Organic Chemistry biology.organism_classification Antineoplastic Agents Phytogenic Terpenoid Complementary and alternative medicine chemistry Annonaceae Molecular Medicine Female Diterpenes Drug Screening Assays Antitumor Diterpene |
| Zdroj: | Journal of Natural Products. 72:1960-1963 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np900207z |
| Popis: | Three new clerodane-type diterpenes, 6alpha,16-dihydroxycleroda-3,13-dien-15-oic acid (1), 6alpha,16-dihydroxycleroda-4(18),13-dien-15-oic acid (2), and 4alpha,18beta-epoxy-16-hydroxyclerod-13-en-15-oic acid (3), and four new protoberberine alkaloids, (-)-8-oxo-10-hydroxy-2,3,9-trimethoxyberberine (4), (-)-8-oxo-2,11-dihydroxy-3,10-dimethoxyberberine (5), (-)-8-oxo-11-hydroxy-2,3,9,10-tetramethoxyberberine (6), and (-)-8-oxo-2,10-dihydroxy-3,9,11-trimethoxyberberine (7), together with 11 known substances, were isolated from a methanol extract of the stems of Polyalthia longifolia var. pendula. The structures of 1-7 were elucidated on the basis of spectroscopic data analysis. Compounds were evaluated for their antiproliferative activities against A549 and MCF-7 cancer cells, and among the substances tested, only 16-oxo-cleroda-3,13-dien-15-oic acid (8) exhibited cytotoxicity. |
| Databáze: | OpenAIRE |
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