Optimized neuron models for estimation of charged particle energy deposition in hippocampus
| Autor: | Svetlana V. Aksenova, Oidov Lkhagva, Munkhbaatar Batmunkh, Aleksandr N. Bugay, Lkhagvaa Bayarchimeg |
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| Rok vydání: | 2018 |
| Předmět: |
Monte Carlo method
Population Models Neurological Biophysics General Physics and Astronomy Hippocampus Hippocampal formation 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine medicine Animals Radiology Nuclear Medicine and imaging education Physics Neurons education.field_of_study Quantitative Biology::Neurons and Cognition Computers Dentate gyrus General Medicine Neural stem cell Charged particle Rats medicine.anatomical_structure 030220 oncology & carcinogenesis Neuron Biological system |
| Zdroj: | Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB). 57 |
| ISSN: | 1724-191X |
| Popis: | The study of evaluating radiation risk on the central nervous system induced by space-born charged particles is very complex and challenging task in space radiobiology and radiation protection. To overcome computational difficulties in this field, we developed simplified neuron models with properties equivalent to realistic neuron morphology. Three-dimensional structure and parameters of simplified and complex neuron models with realistic morphology were obtained from the experimental data. The models implement uniform random distribution of spines along the dendritic branches in typical hippocampal neurons. Both types of models were implemented and tested using Geant4 Monte Carlo radiation transport code. Track structure simulations were performed for ion beams with typical fluxes of galactic cosmic rays expected for long-term interplanetary missions. The distribution of energy deposition events and percentage of irradiated volumes were obtained to be similar in both simplified and realistic models of pyramidal and granule cells of the rat hippocampus following irradiation. Significant increase of computational efficiency for detailed microdosimetry simulations of hippocampus using simplified neuron models was achieved. Using designed neuron models we have constructed 3D model of the rat hippocampus, including pyramidal cells, mature and immature granular cells, mossy cells, and neural stem cells. Computed energy deposition in irradiated hippocampal neurons following a track of iron ion suggests that most of energy is accumulated by dense population of granular cells in the dentate gyrus. Proposed approach could serve as a complementary computation technique for studying radiation-induced effects in large scale brain networks. |
| Databáze: | OpenAIRE |
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