N-phenyl-1-naphthylamine (PNA) Accumulates in Snapping Turtle (Chelydra serpentina) Liver Activating the Detoxification Pathway
| Autor: | John Toito, Valerie S. Langlois, Vimal K. Balakrishnan, Tash-Lynn L. Colson, Shane R. de Solla |
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| Rok vydání: | 2020 |
| Předmět: |
Canada
030310 physiology Health Toxicology and Mutagenesis Animals Wild Cytochrome P450 Common snapping turtle 010501 environmental sciences Toxicology 01 natural sciences Article law.invention 03 medical and health sciences food law Animals Ecotoxicology Turtle (robot) 0105 earth and related environmental sciences 0303 health sciences Toxicity biology Chemistry musculoskeletal neural and ocular physiology Reptiles General Medicine Metabolism biology.organism_classification Pollution food.food Turtles Turtle 1-Naphthylamine Liver Biochemistry biological sciences cardiovascular system biology.protein N-phenyl-1-naphthylamine tissues Phase I Detoxification Chelydra |
| Zdroj: | Bulletin of Environmental Contamination and Toxicology |
| ISSN: | 1432-0800 0007-4861 |
| DOI: | 10.1007/s00128-020-03043-0 |
| Popis: | Substituted phenylamine antioxidants (SPAs) are used in Canadian industrial processes. SPAs, specifically N-phenyl-1-naphthylamine (PNA), have received very little attention despite their current use in Canada and their expected aquatic and environmental releases. There is a research gap regarding the effects of PNA in wildlife; therefore, Chelydra serpentina (common snapping turtle) was studied due to its importance as an environmental indicator species. A chronic experiment was performed using PNA spiked food (0 to 3446 ng/g) to determine its toxicity to juvenile C. serpentina. A significant increase in cyp1a mRNA level was observed in the liver of turtles exposed to 3446 ng/g PNA, suggesting that phase I detoxification is activated in the exposed animals. Additionally, a significant decrease in cyp2b transcript level was observed at the two lowest PNA doses, likely indicating another metabolic alteration for PNA. This study helped determine the molecular effects associated with a PNA exposure in reptiles. |
| Databáze: | OpenAIRE |
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