Evaluation of insulin resistance in obese women with and without acanthosis nigricans
| Autor: | Giti Sadeghian, Masoud Amini, Hengameh Ziaie, Mohhamad Ali Nilfroushzadeh |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Blood Glucose medicine.medical_specialty medicine.medical_treatment Dermatology Iran Insulin resistance Risk Factors Diabetes mellitus Internal medicine medicine Hyperinsulinemia Humans Insulin Acanthosis Nigricans Obesity Acanthosis nigricans Glucose tolerance test medicine.diagnostic_test business.industry Case-control study General Medicine Glucose Tolerance Test Middle Aged medicine.disease Lipids Cross-Sectional Studies Endocrinology Case-Control Studies Female Insulin Resistance business |
| Zdroj: | The Journal of Dermatology. 36:209-212 |
| ISSN: | 1346-8138 0385-2407 |
| DOI: | 10.1111/j.1346-8138.2009.00625.x |
| Popis: | Acanthosis nigricans is characterized by hyperpigmented velvety plaques of body folds and neck. Insulin could be a responsible factor in the pathogenesis of this condition and hyperinsulinemia: a consequence of insulin resistance stimulates the formation of these characteristic plaques. In this study, insulin resistance was compared in obese women with and without acanthosis nigricans. This was a cross-sectional study. Sixty-six obese women (32 patients with acanthosis nigricans and 34 patients without acanthosis nigricans) were selected randomly. Levels of fasting serum insulin and fasting blood glucose were measured in both groups and insulin resistance was determined using homeostasis model assessment. Glucose tolerance test also was performed for all of participants. Five (15.6%) patients with acanthosis nigricans and no (0%) patient without acanthosis nigricans had insulin resistance (P < 0.05). Six (18.7%) patients with acanthosis nigricans and one (2.9%) patient without acanthosis nigricans had impaired glucose tolerance test (P < 0.05). The mean levels of fasting serum insulin were 15.7 +/- 8.7 and 12.2 +/- 4.1 microm/mL (P < 0.05) and the mean values of insulin resistance index were 3.5 +/- 1.9 and 2.6 +/- 0.9 microm/mL between patients with and without acanthosis nigricans, respectively (P < 0.05). In Iranian obese women, acanthosis nigricans is a marker of insulin resistance. |
| Databáze: | OpenAIRE |
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