Association Of Hyponatremia And Hypovitaminosis D In Ambulatory Adults
| Autor: | Giuseppe Lippi, Gian Luca Salvagno, Patrizia Bonelli, Laura Bonfanti, Gianfranco Cervellin, Gian Cesare Guidi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Sodium Osteoporosis Population chemistry.chemical_element Poison control vitamin D elderly osteoporoza vitamin D deficiency lcsh:Biochemistry Internal medicine medicine Vitamin D and neurology lcsh:QD415-436 education sodium education.field_of_study Original Paper business.industry Vit D nutritional and metabolic diseases stare osobe hiponatrijemija natrijum medicine.disease osteoporosis Surgery chemistry Ambulatory Hyponatremia vitamin D Vit D business Hyponatremia |
| Zdroj: | Journal of Medical Biochemistry, Vol 34, Iss 4, Pp 450-454 (2015) Journal of Medical Biochemistry |
| Popis: | Hyponatremia and vitamin D deficiency are frequent disorders, and both have been associated with gait disturbances, falls and fractures. The aim of this study was to evaluate the existence of an association between serum sodium and vitamin D serum levels.We performed a retrospective investigation to establish whether hyponatremia and vitamin D deficiency may be associated in a general population of unselected outpatients. An electronic search was performed in the laboratory information systems of the Hospital of Verona and the Hospital of Parma (Italy), to retrieve combined results for total vitamin D and sodium obtained in all outpatients referred for health check-up in the year 2013.Combined results of vitamin D and sodium could be retrieved for 5097 outpatients (3859 females and 1238 males; mean age 64±17 years). Vitamin D deficient subjects displayed significantly lower levels of serum sodium (140 versus 141 mmol/L; p0.001), along with a significantly higher rate of hyponatremia (6.3% versus 5.1%; p=0.037). Accordingly, hyponatremic subjects had significantly lower levels of serum vitamin D (55 versus 60 nmol/L; p=0.015), along with a significantly higher rate of vitamin D deficiency (41.8% versus 36.1%; p=0.030). A highly significant correlation was found between sodium and total vitamin D after adjustment for age and gender (p0.001).The results of this study demonstrate for the first time the existence of a significant correlation between the serum levels of sodium and total vitamin D in a general population of unselected outpatients.Hiponatrijemija i nedostatak vitamina D su česti poremećaji i povezani su sa teškoćama u hodu, padovima i prelomima. Cilj ove studije bio je da se utvrdi da li postoji povezanost između natrijuma u serumu i nivoa vitamina D u serumu.Sproveli smo retrospektivno istraživanje da bismo utvrdili postojanje veze između hiponatrijemije i nedostatka vitamina D u opštoj populaciji bolesnika. Izvršena je elektronska pretraga laboratorijskih informacionih sistema Bolnice u Veroni i Bolnice u Parmi (Italija), kako bi se dobili kombinovani rezultati za ukupni vitamin D i natrijum za sve bolesnike koji su upućeni na zdravstveni pregled tokom 2013.Kombinovani rezultati za vitamin D i natrijum dobijeni su za 5097 bolesnika (3859 žena i 1238 muškaraca; prosečna starost 64±17 godina). Kod pacijenata s nedostatkom vitamina D nađeni su značajno niži nivoi natrijuma u serumu (140 prema 141 mmol/L; p0,001), kao i značajno viša stopa hiponatrijemije (6,3% prema 5,1%; p=0,037). U skladu s tim, bolesnici sa hiponatrijemijom imali su značajno niže nivoe vitamina D u serumu (55 prema 60 nmol/L; p=0,015), kao i značajno višu stopu deficijencije vitamina D (41,8% prema 36,1%; p=0,030). Pronađena je veoma značajna korelacija između natrijuma i ukupnog vitamina D posle prilagođavanja za uzrast i pol (p0,001).Rezultati ove studije prvi put su pokazali da postoji značajna korelacija između nivoa natrijuma u serumu i ukupnog vitamina D u opštoj populaciji neselektovanih bolesnika. |
| Databáze: | OpenAIRE |
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