Studies on an Immunologically Induced Synovitis Model in Pigs and Sheep
| Autor: | Abel Hh, Uda Schramm, Wethling H, Hohlbach G, B. M. Lind, K. Karcher, K. O. Möller |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Turkeys
medicine.medical_specialty Pathology Ovalbumin Swine Freund's Adjuvant Plasma Cells Inflammation Injections Intra-Articular Arthroscopy Antigen Synovitis Synovial Fluid Animals Medicine Synovial fluid Orthopedics and Sports Medicine Lymphocytes Antigens Sensitization Autoimmune disease Antigens Bacterial Sheep business.industry Albumin Endoscopy Mycobacterium tuberculosis General Medicine medicine.disease Hindlimb Disease Models Animal medicine.anatomical_structure Chronic Disease Immunology Immunization Surgery Histopathology Laser Therapy medicine.symptom business Chickens |
| Zdroj: | Clinical Orthopaedics and Related Research. 361:228-236 |
| ISSN: | 0009-921X |
| DOI: | 10.1097/00003086-199904000-00029 |
| Popis: | Chronic synovitis was induced in seven sheep and nine pigs to investigate the potential applicability of laser treatment in arthroscopic synovectomy. Systemic sensitization was accomplished using chicken egg or turkey egg albumin antigens with Freund's incomplete adjuvant, enriched with killed and dried Mycobacterium tuberculosis. Ten days after the second immunizing dose, skin sensitization testing was undertaken. After a satisfactory systemic reaction had been observed, the respective antigen was injected once or twice into the left knee of each animal at 2-week intervals. After chicken egg albumin sensitization at varying systemic immunization and joint injection doses, sheep (five of five) showed neither strong morphologic nor continuous synovitis, despite a positive systemic reaction. In pigs (three of three) the inflammatory signs also were unsatisfactory for the manifestation and characterization of a synovitis model. In contrast, the application of turkey egg albumin to pigs (six of six) during the 4-month study provided a persistent, clearly manifested synovitis that developed visible villi formation and an amber to gray synovial fluid and microscopically showed follicular aggregations of lymphocytes and plasma cells. In similarly immunized sheep (two of two), only a light synovitis developed with occasional perivascular inflammatory foci. |
| Databáze: | OpenAIRE |
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