Effect of human papillomavirus vaccination on cervical cancer screening in Alberta
| Autor: | Gordon Kliewer, Christopher A. Bell, Huiming Yang, Jong Kim, Maria McInerney, Linan Xu, Maggie C. Sun, Lawrence W. Svenson |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Population Uterine Cervical Neoplasms Alberta 03 medical and health sciences 0302 clinical medicine medicine Humans Mass Screening 030212 general & internal medicine Pap test education Papillomaviridae Early Detection of Cancer Mass screening Vaginal Smears education.field_of_study medicine.diagnostic_test Obstetrics business.industry Research Papillomavirus Infections General Medicine Odds ratio medicine.disease Surgery Vaccination Squamous intraepithelial lesion 030220 oncology & carcinogenesis Cohort Population study business |
| Zdroj: | Canadian Medical Association Journal. 188:E281-E288 |
| ISSN: | 1488-2329 0820-3946 |
| Popis: | Background: A school-based program with quadrivalent human papillomavirus (HPV) vaccination was implemented in Alberta in 2008. We assessed the impact of this program on Pap test cytology results using databases of province-wide vaccination and cervical cancer screening. Methods: We conducted a nested case-control study involving a cohort of women in Alberta born between 1994 and 1997 who had at least 1 Pap test between 2012 and 2015. Women with negative cytology results were controls. Women with low-grade (atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesion) and high-grade (atypical squamous cells, cannot rule out a high-grade lesion; or high-grade squamous intraepithelial lesion) cervical abnormalities were cases. Exposure status was assigned according to records of HPV vaccination. Odds ratios (ORs) for abnormal cytology results by vaccination status were adjusted for neighbourhood income, laboratory service, rural versus urban residency, and age. Results: The total study population was 10 204. Adjusting for age, vaccinated women had a higher screening rate than unvaccinated women (13.0% v. 11.4%, p Interpretation: Quadrivalent HPV vaccination significantly reduced high-grade cervical abnormalities but required 3 doses. Vaccination against HPV was associated with screening uptake. Population-based vaccination and screening programs should work together to optimize cervical cancer prevention. |
| Databáze: | OpenAIRE |
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