Vagus nerve stimulation during rehabilitative training enhances recovery of forelimb function after ischemic stroke in aged rats
| Autor: | Thelma Bethea, Andrea Ruiz, Navid Khodaparast, Robert L. Rennaker, Jason B. Carmel, Seth A. Hays, Michael P. Kilgard |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Aging medicine.medical_specialty medicine.medical_treatment Neuroscience(all) Clinical Neurology Isometric exercise Motor Activity Article Lesion 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation Physical Conditioning Animal Forelimb medicine Animals Humans Stroke Rehabilitation General Neuroscience Motor Cortex Stroke Rehabilitation Vagus Nerve medicine.disease Electric Stimulation Rats Inbred F344 Vagus nerve Disease Models Animal Ageing 030104 developmental biology medicine.anatomical_structure Female Neurology (clinical) medicine.symptom Geriatrics and Gerontology Psychology 030217 neurology & neurosurgery Vagus nerve stimulation Physical Conditioning Human Motor cortex Developmental Biology |
| Zdroj: | Neurobiology of Aging. 43:111-118 |
| ISSN: | 0197-4580 |
| DOI: | 10.1016/j.neurobiolaging.2016.03.030 |
| Popis: | Advanced age is associated with a higher incidence of stroke and worse functional outcomes. Vagus nerve stimulation (VNS) paired with rehabilitative training has emerged as a potential method to improve recovery after brain injury but to date has only been evaluated in young rats. Here, we evaluated whether VNS paired with rehabilitative training would improve recovery of forelimb function after ischemic lesion of the motor cortex in rats 18 months of age. Rats were trained to perform the isometric pull task, an automated, quantitative measure of volitional forelimb strength. Once proficient, rats received an ischemic lesion of the motor cortex and underwent rehabilitative training paired with VNS for 6 weeks. VNS paired with rehabilitative training significantly enhances recovery of forelimb function after lesion. Rehabilitative training without VNS results in a 34% ± 19% recovery, whereas VNS paired with rehabilitative training yields a 98% ± 8% recovery of prelesion of forelimb function. VNS does not significantly reduce lesion size. These findings demonstrate that VNS paired with rehabilitative training enhances motor recovery in aged subjects in a model of stroke and may suggest that VNS therapy may effectively translate to elderly stroke patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect