Qualitative Detection of Proviral-DNA of HIV-1 In Infants To Determine The Efficacy of Antiretroviral Therapy In The Prevention of Vertical Transmission of HIV-1 In The Gambia

Autor: Lamin B. Cham, Ousman Bah P, Sembène PM, Ceesay M, Joof E, Kebbeh A, Gueye M, Njie E, Sanneh B
Rok vydání: 2017
Předmět:
DOI: 10.6084/m9.figshare.5674753
Popis: Background: The priority of the Gambia government is to eliminate maternal to child transmission of HIV and in line with this priority, the country implemented an antiretroviral therapy (ART) program. With this, all HIV infected pregnant and breastfeeding mothers and infants have access to ARV drugs. This study aims to determine the prevalence of vertical transmission of HIV among women receiving the ARV drugs. Methods: Dried blood spot samples were collected from 109 HIV-exposed infants enrolled in 13 PMTCT sites across the country. A qualitative detection of proviral-DNA of HIV-1 was performed using the Real Time Abbott PCR assay. Data from 105 mothers were analyzed using SPSS version 16.0 and association of risk factors to PCR results were analyzed using (Crosstabs) Pearson Chi-Square. The p-value of significant was set at p
Databáze: OpenAIRE