Gonad-gonadotrope interactions: plasma gonadotrophin levels and tumour induction in long-term castrated rats
| Autor: | Diane Kourelakos, Jacob Furth, Daniel M. Linkie |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Time Factors Gonad Endocrinology Diabetes and Metabolism Radioimmunoassay Biology Gonadotropic cell Endocrinology Pituitary Gland Anterior Thyrotropic cell Internal medicine Testis medicine Animals Pituitary Neoplasms Castration Gonadotrophin levels Ovary Tumour induction Neoplasms Experimental General Medicine Luteinizing Hormone Rats medicine.anatomical_structure Immunohistochemistry Female Corticotropic cell Follicle Stimulating Hormone Hormone |
| Zdroj: | Acta Endocrinologica. 97:181-185 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/acta.0.0970181 |
| Popis: | The patterns of gonadotrophin secretion in intact controls and in male and female rats castrated for up to 36 months were established utilizing specific radioimmunoassay methods. Plasma LH increased 14– 16-fold and FSH rose 4–8-fold in rats of either sex in the first 30 days following gonadectomy. The subsequent 30 day interval showed an additional 76% increase of LH in both sexes and increases in FSH of 32 and 61% in males and females, respectively. These levels were maintained for an additional 34 months. The number of hypophyseal gonadotrophin containing cells, studied by immunohistochemical localization techniques, increased following gonad removal in a pattern similar to that for the circulating hormones. Development of gonadotrophin secreting tumours did not correlate with plasma gonadotrophin concentrations which suggests that the gonadotropes are uniquely resistant to tumourogenesis unlike mammotropes, thyrotropes, and corticotropes. |
| Databáze: | OpenAIRE |
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