Evidence for Genetic Regulation of Susceptibility to Toxoplasmic Encephalitis in AIDS Patients
| Autor: | Jeffrey Fessel, Jack S. Remington, Yasuhiro Suzuki, B. Ruf, Andrew R. Zolopa, Francolse Schumacher-Perdreau, Jose G. Montoya, Sin-Yew Wong, Matthias Schrappe, F. Carl Grumet, Amy Portmore, Byron William Brown, Stefan Köppen |
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| Rok vydání: | 1996 |
| Předmět: |
CD4-Positive T-Lymphocytes
Genetic Markers medicine.medical_specialty Genotype Human leukocyte antigen Gene Frequency Acquired immunodeficiency syndrome (AIDS) HLA-DQ Antigens Immunopathology Internal medicine medicine Humans Immunology and Allergy Sida AIDS-Related Opportunistic Infections biology business.industry medicine.disease biology.organism_classification Toxoplasmosis CD4 Lymphocyte Count Infectious Diseases Genetic marker Toxoplasmosis Cerebral Immunology Encephalitis Disease Susceptibility Viral disease business |
| Zdroj: | The Journal of Infectious Diseases. 173:265-268 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/173.1.265 |
| Popis: | The frequency of HLA-DQ antigens in AIDS patients with toxoplasmic encephalitis (TE) were examined. HLA-DQ3 was significantly more frequent in white North American AIDS patients with TE (85.0%) than in the general white population (51.8%; P = .007, corrected P = .028) or randomly selected control AIDS patients who had not developed TE (40.0%; P = .016). In contrast, the frequency of HLA-DQ1 was lower in TE patients than in healthy controls (40.0% vs. 66.5%, P = .027), but this difference did not reach statistical significance when corrected for the number of variables tested (corrected P = .108 for the general white population). HLA-DQ3 thus appears to be a genetic marker of susceptibility to development of TE in AIDS patients, and DQ1 may be a resistance marker. These HLA associations with disease indicate that development of TE in AIDS patients is affected by a gene or genes in the HLA complex and that HLA-DQ typing may help in decisions regarding TE prophylaxis. |
| Databáze: | OpenAIRE |
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