Identifying loci for the overlap between attention-deficit/hyperactivity disorder and autism spectrum disorder using a genome-wide QTL linkage approach
| Autor: | Ruud B. Minderaa, Hans-Christoph Steinhausen, Aribert Rothenberger, Ana Miranda, Nanda Rommelse, Stephen V. Faraone, Herbert Roeyers, Ellen A. Fliers, Jan K. Buitelaar, Marieke E. Altink, Luise Poustka, Catharina A. Hartman, Richard Anney, Edmund J.S. Sonuga-Barke, Alejandro Arias-Vasquez, Cathelijne J. M. Buschgens, Michael Gill, Richard P. Ebstein, Philip Asherson, Tobias Banaschewski, Fernando Mulas, Joseph A. Sergeant, Robert D. Oades, Barbara Franke, Pieter J. Hoekstra, Judith S. Nijmeijer |
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| Přispěvatelé: | Faculteit Medische Wetenschappen/UMCG, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Life Course Epidemiology (LCE) |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Male
Medizin Genome-wide association study Comorbidity Personality Assessment 0302 clinical medicine Developmental and Educational Psychology Perception and Action [DCN 1] GENETIC INFLUENCES Child GENERAL-POPULATION 0303 health sciences Mental Health [NCEBP 9] Communication Chromosome Mapping Psychiatry and Mental health comorbidity Autism spectrum disorder Female Psychology linkage Functional Neurogenomics [DCN 2] TRAITS medicine.medical_specialty Adolescent Psychometrics SUSCEPTIBILITY LOCI DEFICIT HYPERACTIVITY DISORDER Quantitative Trait Loci autism spectrum disorder Quantitative trait locus Polymorphism Single Nucleotide behavioral disciplines and activities Article TWIN SAMPLE Genomic disorders and inherited multi-system disorders [IGMD 3] 03 medical and health sciences Genetic linkage mental disorders medicine Pervasive developmental disorder Attention deficit hyperactivity disorder ADHD Humans Genetic Predisposition to Disease Genetic Testing SOCIAL-BEHAVIOR Psychiatry Social Behavior 030304 developmental biology Chromosome Aberrations Chromosomes Human Pair 15 PERVASIVE DEVELOPMENTAL DISORDERS medicine.disease HOMEOBOX-TRANSCRIPTION-FACTOR Developmental disorder Attention Deficit Disorder with Hyperactivity Child Development Disorders Pervasive Autism Lod Score Chromosomes Human Pair 18 030217 neurology & neurosurgery Chromosomes Human Pair 16 SCAN Genome-Wide Association Study |
| Zdroj: | JOURNAL OF THe AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY Journal of the American Academy of Child and Adolescent Psychiatry, 49, 7, pp. 675-85 Nijmeijer, J S, Arias-Vásquez, A, Rommelse, N N J, Altink, M E, Anney, R J L, Asherson, P, Banaschewski, T, Buschgens, C J M, Fliers, E A, Gill, M, Minderaa, R B, Poustka, L, Sergeant, J A, Buitelaar, J K, Franke, B, Ebstein, R P, Miranda, A, Mulas, F, Oades, R D, Roeyers, H, Rothenberger, A, Sonuga-Barke, E J S, Steinhausen, H-C, Faraone, S V, Hartman, C A & Hoekstra, P J 2010, ' Identifying loci for the overlap between attention-deficit/hyperactivity disorder and autism spectrum disorder using a genome-wide QTL linkage approach ', American Academy of Child and Adolescent Psychiatry. Journal, vol. 49, no. 7, pp. 675-85 . https://doi.org/10.1016/j.jaac.2010.03.015 Journal of the American Academy of Child and Adolescent Psychiatry, 49, 675-85 Journal of the American Academy of Child and Adolescent Psychiatry, 49(7), 675-685. ELSEVIER SCIENCE INC |
| ISSN: | 0890-8567 |
| DOI: | 10.1016/j.jaac.2010.03.015 |
| Popis: | Contains fulltext : 88211.pdf (Publisher’s version ) (Closed access) OBJECTIVE: The genetic basis for autism spectrum disorder (ASD) symptoms in children with attention-deficit/hyperactivity disorder (ADHD) was addressed using a genome-wide linkage approach. METHOD: Participants of the International Multi-Center ADHD Genetics study comprising 1,143 probands with ADHD and 1,453 siblings were analyzed. The total and subscale scores of the Social Communication Questionnaire (SCQ) were used as quantitative traits for multipoint regression-based linkage analyses on 5,407 autosomal single-nucleotide polymorphisms applying MERLIN-regress software, both without and with inclusion of ADHD symptom scores as covariates. RESULTS: The analyses without ADHD symptom scores as covariates resulted in three suggestive linkage signals, i.e., on chromosomes 15q24, 16p13, and 18p11. Inclusion of ADHD symptom scores as covariates resulted in additional suggestive loci on chromosomes 7q36 and 12q24, whereas the LOD score of the locus on chromosome 15q decreased below the threshold for suggestive linkage. The loci on 7q, 16p, and 18p were found for the SCQ restricted and repetitive subscale, that on 15q was found for the SCQ communication subscale, and that on 12q for the SCQ total score. CONCLUSIONS: Our findings suggest that QTLs identified in this study are ASD specific, although the 15q QTL potentially has pleiotropic effects for ADHD and ASD. This study confirms that genetic factors influence ASD traits along a continuum of severity, as loci potentially underlying ASD symptoms in children with ADHD were identified even though subjects with autism had been excluded from the IMAGE sample, and supports the hypothesis that differential genetic factors underlie the three ASD dimensions. 01 juli 2010 |
| Databáze: | OpenAIRE |
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