Obese children aged 4-6 displayed decreased fasting and postprandial ghrelin levels in response to a test meal
| Autor: | Kristina Thorngren-Jerneck, Jenny Önnerfält, Caroline Montelius, Charlotte Erlanson-Albertsson |
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| Rok vydání: | 2018 |
| Předmět: |
Blood Glucose
Male Pediatric Obesity medicine.medical_specialty medicine.medical_treatment 030209 endocrinology & metabolism Body Mass Index Hospitals University Eating 03 medical and health sciences 0302 clinical medicine Reference Values Internal medicine Humans Insulin Medicine 030212 general & internal medicine Child Breakfast Retrospective Studies Sweden Meal business.industry digestive oral and skin physiology Fasting General Medicine Postprandial Period medicine.disease Obesity Ghrelin Endocrinology Postprandial Case-Control Studies Child Preschool Pediatrics Perinatology and Child Health Female Insulin Resistance Energy Metabolism business Body mass index Homeostasis Hormone |
| Zdroj: | Acta Paediatrica. 107:523-528 |
| ISSN: | 0803-5253 |
| DOI: | 10.1111/apa.14165 |
| Popis: | Aim: Ghrelin is a hunger hormone that plays a role in glucose homoeostasis and its levels increase before a meal and decrease during and after eating. This study compared the fasting ghrelin and insulin levels of obese children aged 4–6 with those of normal weight children and tested postprandial ghrelin levels in the obese children after a standard breakfast. Methods: We recruited 67 children at Lund University Hospital from 2008 to 2011. They comprised 30 obese children from a weight study and 37 normal weight children receiving minor elective surgery. Their mean ages were 4.7 ± 0.6 and 4.3 ± 0.8 years, respectively. The obese children ate a standard breakfast, and postprandial ghrelin was measured after 60 minutes. Results: The obese children had lower ghrelin levels than the controls (p < 0.01). A significant inverse relation was found between body mass index and fasting ghrelin levels. Obese children had significantly lower fasting ghrelin levels after a standard breakfast (p < 0.01), but there were no gender-related differences. Conclusion: Obese children aged 4–6 years had reduced ghrelin and increased insulin levels in the fasting state and postprandial ghrelin was suppressed, suggesting that their energy metabolism was already dysregulated at this young age. Early obesity interventions are essential. (Less) |
| Databáze: | OpenAIRE |
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