Polymorphisms of matrix metalloproteinase-7 and -9 are associated with oral tongue squamous cell carcinoma
| Autor: | Silvia Regina Batistuzzo de Medeiros, Leorik Pereira da Silva, Lélia Batista de Souza, Felipe Rodrigues de Matos, Thayse Azevedo da Silva, George João Ferreira do Nascimento, Roseana de Almeida Freitas |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Genotype
Single-nucleotide polymorphism Polymorphism Single Nucleotide Metastasis 03 medical and health sciences 0302 clinical medicine medicine Carcinoma Humans Genetic Predisposition to Disease General Materials Science 030212 general & internal medicine Allele Mouth neoplasm business.industry Case-control study Promoter RK1-715 030206 dentistry medicine.disease Metalloproteinases Tongue Neoplasms Matrix Metalloproteinase 9 Case-Control Studies Matrix Metalloproteinase 7 Dentistry Carcinoma Squamous Cell Cancer research Mouth Neoplasms business |
| Zdroj: | Brazilian Oral Research, Vol 35 (2020) Brazilian Oral Research, Volume: 35, Article number: e019, Published: 23 NOV 2020 Brazilian Oral Research v.35 2021 Brazilian Oral Research Sociedade Brasileira de Pesquisa Odontológica (SBPqO) instacron:SBPQO |
| ISSN: | 1807-3107 |
| Popis: | Matrix degradation is an important event in the progression, invasion and metastasis of malignant head and neck lesions. Imbalances, mutations and polymorphisms of MMPs and their inhibitors are observed in several cancer subtypes. The aim of this study was to evaluate the association of the MMP-7 gene promoter (181 A/G) and MMP-9 (-1562 C/T) polymorphisms in oral tongue squamous cell carcinoma (OTSCC). MMP-7 (rs11568818) and MMP-9 (rs3918242) single-nucleotide polymorphisms (SNPs) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis in 71 cases of OTSCC. Normal tissue specimens were obtained from 60 healthy volunteers to serve as the control. The MMP-7 G allele and MMP-9 T allele were more frequent in the OTSCC group than the control group, but only when these two SNPs were taken together was a significant association found with the nodal metastasis of OTSCC (p < 0.001). Based on our results, SNPs in the promoter region of MMP-7 and MMP-9 appear to be associated with greater risk of developing OTSCC, and with a higher propensity to form metastatic tumors. In this respect, molecular studies investigating polymorphisms may be useful in predicting tumor behavior. |
| Databáze: | OpenAIRE |
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