Verapamil inhibits scar formation after peripheral nerve repair in vivo
| Autor: | Qishun Huang, Jing-xiu Deng, Zhenbing Chen, Zhi-wei Liu, Pan Zhou, Huaiyuan Zheng, A-chao Han |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
verapamil
Adhesion (medicine) sciatic nerve Pharmacology scar lcsh:RC346-429 Extracellular matrix 03 medical and health sciences 0302 clinical medicine Developmental Neuroscience In vivo medicine nerve regeneration Fibroblast lcsh:Neurology. Diseases of the nervous system Chemistry type III collagen 030206 dentistry Anatomy Nerve injury medicine.disease type I collagen medicine.anatomical_structure Verapamil nerve injury Sciatic nerve medicine.symptom neural regeneration 030217 neurology & neurosurgery Type I collagen Research Article medicine.drug |
| Zdroj: | Neural Regeneration Research, Vol 11, Iss 3, Pp 508-511 (2016) Neural Regeneration Research |
| ISSN: | 1673-5374 |
| Popis: | The calcium channel blocker, verapamil, has been shown to reduce scar formation by inhibiting fibroblast adhesion and proliferation in vitro. It was not clear whether topical application of verapamil after surgical repair of the nerve in vivo could inhibit the formation of excessive scar tissue. In this study, the right sciatic nerve of adult Sprague-Dawley rats was transected and sutured with No. 10-0 suture. The stoma was wrapped with gelfoam soaked with verapamil solution for 4 weeks. Compared with the control group (stoma wrapped with gelfoam soaked with physiological saline), the verapamil application inhibited the secretion of extracellular matrix from fibroblasts in vivo, suppressed type I and III collagen secretion and increased the total number of axons and the number of myelinated axons. These findings suggest that verapamil could reduce the formation of scar tissue and promote axon growth after peripheral nerve repair. |
| Databáze: | OpenAIRE |
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