Class A1 scavenger receptor modulates glioma progression by regulating M2-like tumor-associated macrophage polarization
| Autor: | Hui Bai, Jingjing Ben, Qing Yang, Qi Chen, Yong Xu, Xudong Zhu, Ruoyu Dang, Wenbin Zhang, Yan Zhang, Hanwen Zhang, Rong-Mei Zhou, Xuan Sun |
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| Rok vydání: | 2016 |
| Předmět: |
Male
STAT3 Transcription Factor 0301 basic medicine Pathology medicine.medical_specialty Angiogenesis macrophage polarization Macrophage polarization Tumor-associated macrophage class A1 scavenger receptor Monocytes tumor-associated macrophage Mice 03 medical and health sciences 0302 clinical medicine Glioma medicine Animals Humans Macrophage heat shock protein 70 HSP70 Heat-Shock Proteins Neoplasm Invasiveness Scavenger receptor Cell Proliferation Tumor microenvironment Serine-Arginine Splicing Factors Microglia Brain Neoplasms business.industry Macrophages Prognosis medicine.disease Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Disease Progression Female Neoplasm Recurrence Local STAT6 Transcription Factor business Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.10318 |
| Popis: | // Hanwen Zhang 1 , Wenbin Zhang 2 , Xuan Sun 1 , Ruoyu Dang 1 , Rongmei Zhou 1 , Hui Bai 1 , Jingjing Ben 1 , Xudong Zhu 1 , Yan Zhang 1 , Qing Yang 1 , Yong Xu 1 , Qi Chen 1 1 Department of Pathophysiology, Nanjing Medical University, Nanjing, P.R. China 2 Department of Neurosurgery, Brain Hospital affiliated to Nanjing Medical University, Nanjing, P.R. China Correspondence to: Qi Chen, email: qichen@njmu.edu.cn Keywords: glioma, tumor-associated macrophage, class A1 scavenger receptor, macrophage polarization, heat shock protein 70 Received: December 02, 2015 Accepted: June 12, 2016 Published: June 29, 2016 ABSTRACT Macrophages enhance glioma development and progression by shaping the tumor microenvironment. Class A1 scavenger receptor (SR-A1), a pattern recognition receptor primarily expressed in macrophages, is up-regulated in many human solid tumors. We found that SR-A1 expression in 136 human gliomas was positively correlated with tumor grade (P |
| Databáze: | OpenAIRE |
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