Association between blood polyunsaturated fatty acid levels and depressive symptoms in breast cancer survivors
Autor: | Kei Hamazaki, Yutaka Matsuoka, Takayuki Kinoshita, Ryo Okubo, Masayuki Sekiguchi, Jin-zhong Xiao, Tomomi Narisawa, Noriko Katsumata, Yasuhito Uezono, Hiroko Noguchi |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Clinical Biochemistry Breast Neoplasms Hospital Anxiety and Depression Scale law.invention Linoleic Acid 03 medical and health sciences 0302 clinical medicine Breast cancer Cancer Survivors Randomized controlled trial law Internal medicine Fatty Acids Omega-3 medicine Humans Prospective cohort study Depression (differential diagnoses) Aged chemistry.chemical_classification 030109 nutrition & dietetics Depression business.industry Confounding food and beverages Cancer Cell Biology Middle Aged medicine.disease chemistry Female lipids (amino acids peptides and proteins) business human activities 030217 neurology & neurosurgery Polyunsaturated fatty acid |
Zdroj: | Prostaglandins, Leukotrienes and Essential Fatty Acids. 139:9-13 |
ISSN: | 0952-3278 |
Popis: | In contrast to the cumulative evidence suggesting the inverse association of n-3 polyunsaturated fatty acids (PUFAs) with depression, few studies have examined the association of n-6 PUFAs with depression. In particular, no study has examined the relationship between n-6 PUFAs and depression in cancer patients. Thus, we conducted this cross-sectional study to comprehensively examine the association of n-3 and n-6 PUFAs with depressive symptoms in breast cancer survivors. Adults who had been diagnosed with invasive breast cancer and were not undergoing chemotherapy were enrolled. Blood PUFA composition was determined using capillary blood. Depressive symptoms were assessed using the Hospital Anxiety and Depression Scale (HADS). Among 126 participants, the mean age (standard deviation) was 58 (11) years and 47% had stage I cancer. Multiple regression analysis controlling for possible confounders revealed that the level of total n-6 PUFAs and linoleic acid was significantly associated with the HADS total score (beta = 0.175, p = 0.046 for total n-6 PUFAs; beta = 0.174, p = 0.048 for LA). No significant associations were found for other PUFAs. These findings provide the first evidence suggesting that a higher blood level of total n-6 PUFAs and linoleic acid is significantly associated with higher depressive symptoms among breast cancer survivors. Further studies should examine the positive effects of a reduction in n-6 PUFAs on depressive symptoms in breast cancer survivors using prospective studies, including randomized control trials. |
Databáze: | OpenAIRE |
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