Occult axillary lymph node metastases in breast cancer do matter: results of 10-year survival analysis
| Autor: | Margaret C. Cummings, R G Wright, Ian C. Bennett, Michael A. McGuckin, Michael Walsh, B. G. Hohn |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Oncology
Pathology medicine.medical_specialty Mammary gland Breast Neoplasms Disease-Free Survival Pathology and Forensic Medicine Metastasis Breast cancer Internal medicine Progesterone receptor medicine Carcinoma Humans Lymph node Survival analysis business.industry Carcinoma Ductal Breast Genes erbB-2 medicine.disease Genes p53 Prognosis Primary tumor Survival Analysis medicine.anatomical_structure Receptors Estrogen Lymphatic Metastasis Axilla Surgery Female Anatomy business Follow-Up Studies |
| Zdroj: | The American journal of surgical pathology. 26(10) |
| ISSN: | 0147-5185 |
| Popis: | Axillary lymph node status is one of the most powerful prognostic factors for patients with breast cancer and is often critical in stratifying patients into adjuvant treatment regimens. In 203 apparently node-negative cases of breast cancer, a combination of immunohistochemical staining and step-sectioning identified occult metastases in 25% of cases. Ten-year follow-up information is available for these patients. Histologic features of the primary tumor and immunohistochemical staining for estrogen receptor, progesterone receptor, Her-2, and p53 were also evaluated. With multivariate analysis, both occult metastases and higher histologic grade of the primary tumor were independent predictors of disease-free survival. Histologic grade was the only significant independent predictor of overall survival. Estrogen receptor, progesterone receptor, Her-2, and p53 status did not predict the presence of metastases or survival when all tumor types were considered together. Metastases >0.5 mm significantly predicted a poorer disease-free survival when invasive ductal carcinomas were considered alone. Histologic grade was significantly associated with disease-free survival in the premenopausal and perimenopausal patients but not in the postmenopausal patients. The presence of occult metastases approached significance for overall survival in the premenopausal and perimenopausal patients but not in the postmenopausal patients. |
| Databáze: | OpenAIRE |
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