Metabolic reprogramming in cancer cells, consequences on pH and tumour progression: Integrated therapeutic perspectives with dietary lipids as adjuvant to anticancer treatment

Autor: Lucie Brisson, Pierre Besson, Driffa Moussata, Karine Mahéo, Gaëlle Fromont, Stephan Chevalier, Sébastien Roger, Jean-François Dumas
Přispěvatelé: Nutrition, croissance et cancer (U 1069) (N2C), Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM), Brisson, Lucie, Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Expression des gènes des phosphorylations oxydatives mitochondriales. Maintenance de l'ADN MT, Institut National de la Santé et de la Recherche Médicale (INSERM), Inserm UMR1069, Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'Anatomie et de Cytologie Pathologiques [Poitiers], Centre hospitalier universitaire de Poitiers (CHU Poitiers), Hepato-Gastroenterology, Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Cancer Research
medicine.medical_specialty
Epithelial-Mesenchymal Transition
Bioenergetics
medicine.medical_treatment
[SDV]Life Sciences [q-bio]
Antineoplastic Agents
[SDV.CAN]Life Sciences [q-bio]/Cancer
Disease
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
Biology
Cachexia
03 medical and health sciences
[SDV.CAN] Life Sciences [q-bio]/Cancer
Cancer cell metabolism
Neoplasms
Internal medicine
medicine
Humans
Cancer cell invasiveness
[SDV.BC] Life Sciences [q-bio]/Cellular Biology
ComputingMilieux_MISCELLANEOUS
pH
Autophagy
Cancer
N-3 polyunsaturated fatty acids
Hydrogen-Ion Concentration
medicine.disease
Dietary Fats
Mitochondria
3. Good health
030104 developmental biology
Endocrinology
Anaerobic glycolysis
Cancer cell
Disease Progression
Cancer research
Resistance to treatments
Adjuvant
Zdroj: Seminars in Cancer Biology
Seminars in Cancer Biology, Elsevier, 2017, The new pH-centric Anticancer Paradigm in Oncology and Medicine, 43, pp.90-110. ⟨10.1016/j.semcancer.2017.03.004⟩
Seminars in Cancer Biology, 2017, The new pH-centric Anticancer Paradigm in Oncology and Medicine, 43, pp.90-110. ⟨10.1016/j.semcancer.2017.03.004⟩
Seminars in Cancer Biology, Elsevier, 2017, 43, pp.90-110. ⟨10.1016/j.semcancer.2017.03.004⟩
ISSN: 1044-579X
1096-3650
DOI: 10.1016/j.semcancer.2017.03.004⟩
Popis: International audience; While tumours arise from acquired mutations in oncogenes or tumour-suppressor genes, it is clearly established that cancers are metabolic diseases characterized by metabolic alterations in tumour cells, and also non-tumour cells of the host organism resulting in tumour cachexia and patient weakness. In this review, we aimed at delineating details by which metabolic alterations in cancer cells, characterized by mitochondrial bioenergetics deregulations and the preference for aerobic glycolysis, are critical parameters controlling the aggressive progression of tumours. In particular, metabolic alteration in cancer cells are coupled to the modulation of intracellular and extracellular pH, epithelial-to-mesenchymal transition and associated increased invasiveness, autophagy, and the development of anticancer treatment resistance. Finally, based on mechanistic, pre-clinical and clinical studies, we proposed the adjuvant supplementation of dietary n-3 polyunsaturated fatty acids for a complementary holistic treatment of the cancer disease.
Databáze: OpenAIRE
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