Trends in Microbiological and Antibiotic Sensitivity Patterns in Infectious Keratitis: 10-Year Experience in Mexico City
| Autor: | Enrique O Graue-Hernandez, Luis Antonio Bautista-Hernández, Mariana Ortiz-Casas, Nadia Luz López-Espinosa, Arturo Ramirez-Miranda, Carolina Gaona-Juárez, Victor Manuel Bautista-de Lucio, Julio C. Hernandez-Camarena, Lucero Pedro-Aguilar, Alejandro Navas |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Antibiotic sensitivity Microbial Sensitivity Tests Infectious Keratitis Biology Gram-Positive Bacteria Eye Infections Bacterial Internal medicine Mexico city Drug Resistance Bacterial Gram-Negative Bacteria medicine Humans Child Corneal Ulcer Mexico Gram-Positive Bacterial Infections Aged Retrospective Studies Aged 80 and over Infant Retrospective cohort study Eye infection Middle Aged Surgery Anti-Bacterial Agents Ophthalmology Child Preschool Female Gram-Negative Bacterial Infections |
| Zdroj: | Cornea. 34(7) |
| ISSN: | 1536-4798 |
| Popis: | To report the distribution and trends in microbiological and antibiotic sensitivity patterns of infectious keratitis in a 10-year period at a reference center in Mexico City.In this retrospective observational case series, samples were obtained from corneas with a diagnosis of infectious keratitis from January 2002 to December 2011 at the Institute of Ophthalmology "Conde de Valenciana" in Mexico City. Results of cultures, stains, and specific sensitivity/resistance antibiograms for each microorganism were analyzed.A total of 1638 consecutive corneal scrapings were analyzed. Pathogen was recovered in 616 samples (38%), with bacterial keratitis accounting for 544 of the positive cultures (88%). A nonsignificant increasing trend in gram-negative isolates (P = 0.11) was observed. The most commonly isolated pathogen was Staphylococcus epidermidis, and the most common gram-negative isolated species was Pseudomonas aeruginosa. Methicillin-resistant Staphylococcus aureus (MRSA) was present in 45% of the S. aureus isolates; meanwhile, 53.7% coagulase-negative Staphylococcus isolates were methicillin resistant (MRCNS). Pseudomonas aeruginosa resistance to ceftazidime increased from 15% in the first period to 74% for the last 5 years of the study (P = 0.01). The overall sensitivity for vancomycin of MRSA was 87.5%, whereas 99.6% of the MRCNS were sensitive.There was a nonsignificant increase in the recovered gram-positive and gram-negative microorganisms over time. We observed an increased resistance to methicillin in almost half of the MRSA and MRCNS isolates. |
| Databáze: | OpenAIRE |
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