24-Hour Pattern of Plasma Prolactin in the Male Rhesus Monkey and Its Relation to the Sleep/Wake Cycle*
| Autor: | I. Witt, Hans-Jürgen Quabbe, Beate Stolz, Michael Gregor, Christine Bumke-Vogt |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Sleep REM Nocturnal Biology Endocrinology Internal medicine medicine Animals Circadian rhythm Wakefulness Sleep Stages Hormone activity Macaca mulatta Circadian Rhythm Prolactin Nap Sleep deprivation Sleep Deprivation Sleep onset medicine.symptom Sleep hormones hormone substitutes and hormone antagonists Blood sampling |
| Zdroj: | Endocrinology. 110:969-975 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo-110-3-969 |
| Popis: | The 24-h pattern of the plasma PRL concentration was studied in eight male rhesus monkeys. The animals were prepared with chronic right-atrial catheters and electroencephalogram (EEG) electrodes in order to allow frequent blood sampling (every 15 min) and EEG-recordings (together with constant television observation) from an adjacent room for 24 h or various shorter time periods. Hormonal, activity, and EEG profiles were obtained during undisturbed conditions and during nap, sleep, or specific (noise-induced) sleep stage deprivation experiments. During undisturbed conditions, plasma PRL showed two diurnal peaks (0845 and 1630 h) and a nocturnal increase that coincided with the range of sleep onset times. The 24-h maximum was attained at 2230 h. Then PRL slowly decreased during the rest of the night. Nighttime mean PRL was significantly higher than daytime PRL (4.8 ± 0.7 vs. 3.4 ± 0.4 ngeq/ml). During daytime there was a significant positive correlation of PRL to activity/arousal. During the night, the PRL... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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