In Amateur Athletes With Type 1 Diabetes, a 9-Day Period of Cycling at Moderate-to-Vigorous Intensity Unexpectedly Increased the Time Spent in a State of Hyperglycemia, Which Was Associated With Impairment in Heart Rate Variability
| Autor: | Bruno Pereira, Elsa Heyman, Julien Boissière, Serge Berthoin, Joris Heyman, Elodie Lespagnol, Olivia Bocock, F.X. Gamelin, Martine Duclos |
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| Přispěvatelé: | Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 (URePSSS), Université d'Artois (UA)-Université de Lille-Université du Littoral Côte d'Opale (ULCO), CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand, Unité de Nutrition Humaine (UNH), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES), Gautier (Department of Diabetes and Endocrinology), Université d'Artois (UA)-Université du Littoral Côte d'Opale (ULCO)-Université de Lille, Université de Rennes (UR), Université de Lille, Univ. Artois, Univ. Littoral Côte d’Opale, Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 [URePSSS], Université de Rennes [UR], Physiotherapy, Human Physiology and Anatomy, Human Physiology and Sports Physiotherapy Research Group |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Endocrinology Diabetes and Metabolism [SDV]Life Sciences [q-bio] Population 030209 endocrinology & metabolism Hypoglycemia 03 medical and health sciences Young Adult 0302 clinical medicine Heart Rate Diabetes mellitus Internal medicine Heart rate Internal Medicine medicine [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] Heart rate variability Humans 030212 general & internal medicine Exercise physiology education Exercise Glycemic Advanced and Specialized Nursing education.field_of_study Type 1 diabetes business.industry Blood Glucose Self-Monitoring Heart [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism Middle Aged medicine.disease Bicycling Diabetes Mellitus Type 1 Autonomic Nervous System Diseases Athletes Hyperglycemia Cardiology Female business Diabetic Angiopathies |
| Zdroj: | Diabetes Care Diabetes Care, American Diabetes Association, 2020, Diabetes Care, 43 (10), pp.2564-2573. ⟨10.2337/dc19-1928⟩ Diabetes Care, 2020, Diabetes Care, 43 (10), pp.2564-2573. ⟨10.2337/dc19-1928⟩ Diabetes Care, American Diabetes Association, In press, 43 (10), pp.2564-2573. ⟨10.2337/dc19-1928⟩ |
| ISSN: | 0149-5992 |
| DOI: | 10.2337/dc19-1928⟩ |
| Popis: | OBJECTIVE In type 1 diabetes, autonomic dysfunction may occur early as a decrease in heart rate variability (HRV). In populations without diabetes, the positive effects of exercise training on HRV are well-documented. However, exercise in individuals with type 1 diabetes, particularly if strenuous and prolonged, can lead to sharp glycemic variations, which can negatively impact HRV. This study explores the impact of a 9-day cycling tour on HRV in this population, with a focus on exercise-induced glycemic excursions. RESEARCH DESIGN AND METHODS Twenty amateur athletes with uncomplicated type 1 diabetes cycled 1,500 km. HRV and glycemic variability were measured by heart rate and continuous glucose monitoring. Linear mixed models were used to test the effects of exercise on HRV, with concomitant glycemic excursions and subject characteristics considered as covariates. RESULTS Nighttime HRV tended to decrease with the daily distance traveled. The more time the subjects spent in hyperglycemia, the lower the parasympathetic tone was. This result is striking given that hyperglycemic excursions progressively increased throughout the 9 days of the tour, and to a greater degree on the days a longer distance was traveled, while time spent in hypoglycemia surprisingly decreased. This phenomenon occurred despite no changes in insulin administration and a decrease in carbohydrate intake from snacks. CONCLUSIONS In sports enthusiasts with type 1 diabetes, multiday prolonged exercise at moderate-to-vigorous intensity worsened hyperglycemia, with hyperglycemia negatively associated with parasympathetic cardiac tone. Considering the putative deleterious consequences on cardiac risks, future work should focus on understanding and managing exercise-induced hyperglycemia. |
| Databáze: | OpenAIRE |
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