The Connection between MicroRNAs from Visceral Adipose Tissue and Non-Alcoholic Fatty Liver Disease
| Autor: | Veronika Zubáňová, Otto Kucera, Vladimir Palicka, Zuzana Červinková |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty microrna medicine.medical_treatment Adipose tissue Inflammation Intra-Abdominal Fat Liver transplantation Carbohydrate metabolism nafld 03 medical and health sciences Liver disease 0302 clinical medicine nash Internal medicine lipid metabolism Humans Medicine business.industry Fatty liver non-alcoholic fatty liver disease Lipid metabolism General Medicine medicine.disease digestive system diseases adipose tissue MicroRNAs 030104 developmental biology Endocrinology inflammation 030211 gastroenterology & hepatology non-alcoholic steatohepatitis Steatohepatitis medicine.symptom business mirna |
| Zdroj: | Acta Medica, Vol 64, Iss 1, Pp 1-7 (2021) |
| ISSN: | 1805-9694 1211-4286 |
| Popis: | Non-Alcoholic Fatty Liver Disease (NAFLD) is one of the most important causes of liver disease worldwide leading the foreground cause of liver transplantation. Recently miRNAs, small non-coding molecules were identified as an important player in the negative translational regulation of many protein-coding genes involved in hepatic metabolism. Visceral adipose tissue was found to take part in lipid and glucose metabolism and to release many inflammatory mediators that may contribute to progression of NAFLD from simple steatosis to Non-Alcoholic SteatoHepatitis. Since visceral adipose tissue enlargement and dysregulated levels of miRNAs were observed in patients with NAFLD, the aim of this paper is to reflect the current knowledge of the role of miRNAs released from visceral adipose tissue and NAFLD. |
| Databáze: | OpenAIRE |
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