Case report
| Autor: | Boaz Lopuhaä, King H. Lam, Robert M. Verdijk, Jelle R. Miedema, Johan M. Kros, Willem A. Dik, Jasper van Bommel, Jan H. von der Thüsen |
|---|---|
| Přispěvatelé: | Pathology, Intensive Care, Immunology, Internal Medicine, Pulmonary Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Histology Coronavirus disease 2019 (COVID-19) Case Report Hemophagocytic lymphohistiocytosis Disease 030204 cardiovascular system & hematology Hyperinflammatory syndrome Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Intensive care medicine Hematology business.industry Microvascular thrombosis COVID-19 Pneumonia medicine.disease Thrombosis Pathophysiology 030104 developmental biology business Cytokine storm |
| Zdroj: | Journal of Hematopathology, 14(1), 79-83. Springer-Verlag Journal of Hematopathology |
| ISSN: | 1868-9256 |
| Popis: | The clinical features of COVID-19 have a considerable range from a mild illness to severe disease. Underlying pathophysiological mechanisms of the rapidly progressive, and often fatal, pulmonary disease frequently observed in COVID-19 need to be elucidated, in order to develop new treatment strategies for different disease endotypes. Fatal cases can display features of a cytokine storm, which may be related to hemophagocytic lymphohistiocytosis. Also, a spectrum of vascular changes, including microvascular damage, is known to accompany severe COVID-19. In this paper, we describe the co-occurrence of hemophagocytic lymphohistiocytosis and extensive pulmonary microvascular damage with thrombosis and its sequelae in a patient with fatal COVID-19. We believe these response patterns may be linked by common mechanisms involving hypercytokinemia and require further investigation as a fatal constellation in COVID-19, to generate appropriate treatment in patients who display these combined features. |
| Databáze: | OpenAIRE |
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