Detection of (1,3)-β-d-Glucan for the Diagnosis of Invasive Fungal Infection in Liver Transplant Recipients
Autor: | Sarra El Anbassi, Catherine Cordonnier-Jourdin, Zaid Noorah, Daniel Azoulay, Christine Bonnal, Jean-Claude Merle, Françoise Botterel, Eric Levesque, Nawel Aït-Ammar, Fadi Rizk |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Male Antifungal Agents beta-Glucans medicine.medical_treatment Liver transplantation invasive fungal infection Gastroenterology High morbidity Spectroscopy liver transplantation General Medicine invasive candidiasis Middle Aged Predictive value Computer Science Applications Survival Rate Biomarker (medicine) Female Proteoglycans 3)-β-d<%2Fspan>-glucan%22">">d-glucan invasive pulmonary aspergillosis Adult medicine.medical_specialty 030106 microbiology Biology Chemoprevention Catalysis Article Inorganic Chemistry 03 medical and health sciences Internal medicine medicine Humans Physical and Theoretical Chemistry Mortality Molecular Biology Aged Retrospective Studies Receiver operating characteristic (1 3)-β-d-glucan Organic Chemistry Invasive pulmonary aspergillosis medicine.disease Surgery ROC Curve Septic arthritis 1 3 β d glucan Biomarkers Invasive Fungal Infections |
Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences; Volume 18; Issue 4; Pages: 862 |
ISSN: | 1422-0067 |
Popis: | Invasive fungal infections (IFI) are complications after liver transplantation involving high morbidity and mortality. (1,3)-β-d-glucan (BG) is a biomarker for IFI, but its utility remains uncertain. This study was designed to evaluate the impact of BG following their diagnosis. Between January 2013 and May 2016, 271 liver transplants were performed in our institution. Serum samples were tested for BG (Fungitell®, Associates Cape Code Inc., Falmouth, MA, USA) at least weekly between liver transplantation and the discharge of patients. Nineteen patients (7%) were diagnosed with IFI, including 13 cases of invasive candidiasis (IC), eight cases of invasive pulmonary aspergillosis, and one case of septic arthritis due to Scedosporium apiospernum. Using a single BG sample for the primary analysis of IFI, 95% (21/22) of the subjects had positive BG (>80 pg/mL) at the time of IFI diagnosis. The area under the ROC curves to predict IFI was 0.78 (95% CI: 0.73–0.83). The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of BG for IFI were 75% (95% CI: 65–83), 65% (62–68), 17% (13–21), and 96% (94–97), respectively. Based on their high NPV, the BG test appears to constitute a good biomarker to rule out a diagnosis of IFI. |
Databáze: | OpenAIRE |
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