Detection of (1,3)-β-d-Glucan for the Diagnosis of Invasive Fungal Infection in Liver Transplant Recipients

Autor: Sarra El Anbassi, Catherine Cordonnier-Jourdin, Zaid Noorah, Daniel Azoulay, Christine Bonnal, Jean-Claude Merle, Françoise Botterel, Eric Levesque, Nawel Aït-Ammar, Fadi Rizk
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
Antifungal Agents
beta-Glucans
medicine.medical_treatment
Liver transplantation
invasive fungal infection
Gastroenterology
High morbidity
Spectroscopy
liver transplantation
General Medicine
invasive candidiasis
Middle Aged
Predictive value
Computer Science Applications
Survival Rate
Biomarker (medicine)
Female
Proteoglycans
(1
3)-β-d<%2Fspan>-glucan%22">">d-glucan
invasive pulmonary aspergillosis
Adult
medicine.medical_specialty
030106 microbiology
Biology
Chemoprevention
Catalysis
Article
Inorganic Chemistry
03 medical and health sciences
Internal medicine
medicine
Humans
Physical and Theoretical Chemistry
Mortality
Molecular Biology
Aged
Retrospective Studies
Receiver operating characteristic
(1
3)-β-d-glucan
Organic Chemistry
Invasive pulmonary aspergillosis
medicine.disease
Surgery
ROC Curve
Septic arthritis
1 3 β d glucan
Biomarkers
Invasive Fungal Infections
Zdroj: International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 18; Issue 4; Pages: 862
ISSN: 1422-0067
Popis: Invasive fungal infections (IFI) are complications after liver transplantation involving high morbidity and mortality. (1,3)-β-d-glucan (BG) is a biomarker for IFI, but its utility remains uncertain. This study was designed to evaluate the impact of BG following their diagnosis. Between January 2013 and May 2016, 271 liver transplants were performed in our institution. Serum samples were tested for BG (Fungitell®, Associates Cape Code Inc., Falmouth, MA, USA) at least weekly between liver transplantation and the discharge of patients. Nineteen patients (7%) were diagnosed with IFI, including 13 cases of invasive candidiasis (IC), eight cases of invasive pulmonary aspergillosis, and one case of septic arthritis due to Scedosporium apiospernum. Using a single BG sample for the primary analysis of IFI, 95% (21/22) of the subjects had positive BG (>80 pg/mL) at the time of IFI diagnosis. The area under the ROC curves to predict IFI was 0.78 (95% CI: 0.73–0.83). The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of BG for IFI were 75% (95% CI: 65–83), 65% (62–68), 17% (13–21), and 96% (94–97), respectively. Based on their high NPV, the BG test appears to constitute a good biomarker to rule out a diagnosis of IFI.
Databáze: OpenAIRE
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