The necessity of NEDD8/Rub1 for vitality and its association with mitochondria-derived oxidative stress

Autor: Elah Pick
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Rub1
Clinical Biochemistry
NEDD8
Neural precursor cell Expressed Developmentally Downregulated gene 8
Review Article
Mitochondrion
medicine.disease_cause
Biochemistry
NEDD8
WHB
winged-helix B
Respiratory electron transport chain
COP9 signalosome
0302 clinical medicine
Saccharomycotina
Ub
ubiquitin
lcsh:QH301-705.5
lcsh:R5-920
biology
Ascomycota
Chemistry
UCH
ubiquitin carboxyl terminal hydrolase
CSN
COP9 signalosome
SR
substrate receptor
Mitochondria
Cell biology
Rub1
Related ub 1
HIF-α1
Hypoxia-inducible factor α-1
Ubl
ubiquitin-like
lcsh:Medicine (General)
Pezizomycotina
Cullin-RING E3 ligase
Saccharomyces cerevisiae Proteins
ETC
electron transfer respiratory chain
PCNA
proliferating cell nuclear antigen
Saccharomyces cerevisiae
03 medical and health sciences
ROS
reactive oxygen species
medicine
SUMO
Small Ubiquitin-like Modifier
PARP1
Poly ADP-Ribose Polymerase 1
Ubiquitins
ULP1
Ub Like Protease 1
Organic Chemistry
biology.organism_classification
mtDNA
mitochondrial DNA
Oxidative Stress
Taphrinomycotina
030104 developmental biology
lcsh:Biology (General)
CRLs
cullin-RING E3 ligases
NEDP1
030217 neurology & neurosurgery
Oxidative stress
Zdroj: Redox Biology, Vol 37, Iss, Pp 101765-(2020)
Redox Biology
ISSN: 2213-2317
Popis: Access of molecular oxygen to the respiratory electron transport chain at the mitochondria costs in the generation of reactive oxygen-derived species (ROS). ROS induces progressive damage to macromolecules in all living cells, hence, rapid defense mechanisms to maintain cellular redox homeostasis are vital. NEDD8/Rub1 is a highly conserved ubiquitin-like modifier that has recently been identified as a key regulator of cellular redox homeostasis. In this review, I will present NEDD8/Rub1, its modification cascade of enzymes, substrates and hydrolases. After introduction, I will show that the NEDD8/Rub1 pathway is linked with mitochondria physiology, namely, oxidative stress. In the rest of the review, I will approach the Ascomycota phylum of the kingdom fungi instrumentally, to present existing links between NEDD8/Rub1 vitality and the aerobic lifestyle of model species belonging to three subphyla: Saccharomycotina (S. cerevisiae and C. albicans), Pezizomycotina (A. nidulans and N. crassa), and Taphrinomycotina (S. pombe).
Graphical abstract Image 1
Highlights • NEDD8/Rub1 is a key regulator of cellular redox homeostasis. • Ascomycota species that produce mitochondria-derived ROS during glycolysis require NEDD8/Rub1for viability. • NEDD8/Rub1 essentiality correlates with the existence of NEDP1 in the organism genome.
Databáze: OpenAIRE
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