Xanthogranulomatous disease in the lacrimal gland
| Autor: | David Howarth, H J Williams, W W L Chang, Navdeep Nijhawan, James H. Oestreicher, J Rootman, D Rossman, A DiBartolomeo, Jennifer A. Sivak-Callcott, Valerie A. White, L L Seah, W K Lim |
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| Rok vydání: | 2005 |
| Předmět: |
Pathology
medicine.medical_specialty Letter medicine.diagnostic_test business.industry Necrobiosis Lacrimal gland Anatomy Haematoxylin medicine.disease Sensory Systems Lymphoma Lymphocytic Infiltrate Cellular and Molecular Neuroscience Ophthalmology chemistry.chemical_compound medicine.anatomical_structure chemistry Touton giant cell Granuloma Biopsy medicine business |
| Zdroj: | British Journal of Ophthalmology. 89:1375-1377 |
| ISSN: | 0007-1161 |
| DOI: | 10.1136/bjo.2004.063578 |
| Popis: | We report three cases of adult lacrimal gland xanthoganulomatous disease that demonstrate the spectrum of this disorder and provide insight into immune dysfunction. A 23 year old asthmatic female had 1 year of bilateral, painless, lacrimal gland masses from polyclonal B cell (CD 20+) infiltration (fig 1A, B) The patient was asymptomatic for 18 months after external beam radiation (25 Gy in 10 fractions). While 7 months pregnant, painless lacrimal gland enlargement recurred, as firm, yellow, nodular masses (fig 1C). A second biopsy showed foamy histiocytes, Touton giant cells, and lymphoid infiltrate without necrobiosis (fig 1D). The orbital masses have remained stable 2 years after corticosteroids and surgical debulking. Systemic involvement included breast MALT type lymphoma 4 years after presentation. Figure 1 (A) T1 weighted axial magnetic resonance imaging (MRI) showing bilateral lacrimal gland enlargement. (B) Initial lacrimal gland biopsy showing a dense lymphocytic infiltrate with preserved ducts (haematoxylin and eosin stain, original magnification 4×). (C) Clinical photograph of yellow, recurrent mass, right orbit, 2 years after radiation treatment. (D) Second lacrimal gland biopsy showing Touton giant cells, foamy histiocytes, lymphocytes, and plasma cells (haematoxylin and eosin stain, original magnification 60×). (E) Clinical photograph of patient showing improvement 1 year after treatment. A 49 year old Brunei … |
| Databáze: | OpenAIRE |
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