Differentiating the sedative, psychomotor and amnesic effects of benzodiazepines: a study with midazolam and the benzodiazepine antagonist, flumazenil
| Autor: | Curran Hv, Brian Birch |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Flumazenil Male genetic structures medicine.drug_class Sedation Midazolam Emotions Pharmacology Placebo Flicker Fusion Cognition Double-Blind Method Memory medicine Reaction Time Humans Hypnotics and Sedatives Benzodiazepine business.industry Antagonist Anti-Anxiety Agents Anesthesia Sedative Female Amnesia medicine.symptom Psychomotor disorder business Psychomotor Performance medicine.drug |
| Zdroj: | Psychopharmacology. 103(4) |
| ISSN: | 0033-3158 |
| Popis: | Sixteen healthy volunteers were administered midazolam followed by placebo or the benzodiazepine antagonist, flumazenil, in a double-blind, cross-over study. Flumazenil reversed midazolam-induced sedation on the subjective, psychophysiological and motor indices used. In contrast, there was little evidence of any reversal of amnesic effects, which were assessed using both direct (explicit) and indirect (implicit) measures of memory. Results are discussed in terms of dissociating the sedative and amnesic effects of benzodiazepines. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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