Biomolecular interaction mechanism of an anticancer drug, pazopanib with human serum albumin: a multi-spectroscopic and computational approach
| Autor: | Saharuddin B. Mohamad, Nor Farrah Wahidah Ridzwan, Salanee Kandandapani, Md. Zahirul Kabir, Saad Tayyab |
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| Rok vydání: | 2021 |
| Předmět: |
Indazoles
medicine.drug_class Antineoplastic Agents Serum Albumin Human Tyrosine-kinase inhibitor Pazopanib Structural Biology medicine Humans Molecular Biology Protein Kinase Inhibitors Sulfonamides Binding Sites Diazepam Mechanism (biology) Chemistry Soft tissue sarcoma Circular Dichroism Cancer General Medicine medicine.disease Human serum albumin Anticancer drug Molecular Docking Simulation Pyrimidines Spectrometry Fluorescence Phenylbutazone Cancer research Thermodynamics Warfarin medicine.drug Protein Binding |
| Zdroj: | Journal of biomolecular structuredynamics. 40(18) |
| ISSN: | 1538-0254 |
| Popis: | Pazopanib (PZP) is a multi-targeting tyrosine kinase inhibitor and is currently approved by FDA for the treatment of soft tissue sarcoma and renal cancer. Molecular interaction mechanism of PZP with human serum albumin (HSA) was explored under simulated physiological conditions (pH = 7.4), using fluorescence and UV absorption spectroscopy along with computational methods. Based on the inverse correlation between the Stern-Volmer constant ( |
| Databáze: | OpenAIRE |
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