Biodegradable Screws Containing Bone Morphogenetic Protein-2 in an Osteoporotic Rat Model
| Autor: | Kyoung Hyo Choi, Je Hoon Jeong, Ji Yeon Kim, Sang Ryong Jeon, Joongkee Min, Bora Lee, Eun-Sun Jin |
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| Rok vydání: | 2018 |
| Předmět: |
musculoskeletal diseases
0301 basic medicine Osteoporosis Rat model H&E stain Dentistry Bone morphogenetic protein 2 Proximal metaphysis 03 medical and health sciences 0302 clinical medicine Medicine Tibia Bone mineral business.industry General Neuroscience Screw Animal 030206 dentistry equipment and supplies musculoskeletal system medicine.disease surgical procedures operative 030104 developmental biology Others Models Animal Laboratory Investigation Surgery Neurology (clinical) Implant business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of Korean Neurosurgical Society |
| ISSN: | 1598-7876 2005-3711 |
| Popis: | Objective The aim of this study was to evaluate the effect for biodegradable screws containing bone morphogenetic protein-2 (BMP-2) in an osteoporotic rat model. Methods Twenty-four female Wistar rat (250–300 g, 12 weeks of age) were randomized into four groups. Three groups underwent bilateral ovariectomy (OVX). Biodegradable screws with or without BMP-2 were inserted in the proximal tibia in two implantation groups. The extracted proximal metaphysis of the tibiae were scanned by exo-vivo micro-computed tomography. Evaluated parameters included bone mineral density (BMD), trabecular bone volume (BV/TV), trabecular number, trabecular thickness, and trabecular separation (Tb.Sp). The tibia samples were pathologically evaluated by staining with by Hematoxylin and Eosin, and trichrome. Results Trabecular formation near screw insertion site was evident only in rats receiving BMP-2 screws. BMD and BV/TV significantly differed between controls and the OVX and OVX with screw groups. However, there were no significant differences between control and OVX with screw BMP groups. Tb.Sp significantly differed between control and OVX and OVX with screw groups (p |
| Databáze: | OpenAIRE |
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