Combined multimodal co-registration of PET/CT and MRI images increases diagnostic accuracy in squamous cell carcinoma staging
| Autor: | Alessandro Stecco, Francesco Buemi, Alessandro Carriero, Gian Mauro Sacchetti, Marco Brambilla, Silvio Ciolfi, Alessia Cassarà |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Co registration Multimodal Imaging Sensitivity and Specificity 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Positron Emission Tomography Computed Tomography Medicine Humans Radiology Nuclear Medicine and imaging Basal cell Neuroradiology Aged Neoplasm Staging Retrospective Studies PET-CT business.industry Ultrasound General Medicine Gold standard (test) Middle Aged medicine.disease Head and neck squamous-cell carcinoma Diffusion Magnetic Resonance Imaging Head and Neck Neoplasms 030220 oncology & carcinogenesis Lymphatic Metastasis Carcinoma Squamous Cell Histopathology Female Radiology business |
| Zdroj: | La Radiologia medica. 121(6) |
| ISSN: | 1826-6983 |
| Popis: | The purpose of our study was to assess the diagnostic value of multi-modal imaging through co-registration of short tau inversion recovery (STIR) and diffusion-weighted imaging (DWI) MRI with 18FDG-PET/CT in T and N staging of head and neck tumours. 25 patients with head and neck squamous cell carcinoma who had undergone MRI and PET/CT before treatment were retrospectively evaluated. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of PET/CT, MRI and their combined use were assessed in T and N staging. Histopathology and follow-up imaging results were used as the gold standard. In assessing trans-compartmental extensions, PET-MRI showed 93 % sensitivity, 88 % specificity, 94 % PPV, and 88 % NPV, as compared to the 94 and 53 % sensitivity, 75 and 75 % specificity, 89 and 82 % PPV, and 86 and 43 % demonstrated by MRI and PET, respectively. In the identification of pathological lymph nodes, PET-MRI showed 92 % sensitivity, 89 % specificity, 96 % PPV, and 89 % NPV, whereas PET/CT displayed 72 % sensitivity, 89 % specificity, 95 % PPV and 53 % NPV. The corresponding figures for DWI and STIR sequences were 84 and 100 % sensitivity, 67 and 56 % specificity, 88 and 86 % PPV, and 60 and 100 % NPV, respectively. Multi-modal imaging assessment of co-registered MRI and PET/CT images provides more accurate results for trans-compartmental extensions in T and N staging than the individual techniques alone. |
| Databáze: | OpenAIRE |
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