Dual-encapsulated biodegradable 3D scaffold from liposome and waterborne polyurethane for local drug control release in breast cancer therapy
| Autor: | Feng Luo, Jiehua Li, Hang Yin, Zhen Li, Nijia Song, Hong Tan, Bohong Du, Yue Chen |
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| Rok vydání: | 2020 |
| Předmět: |
Scaffold
Paclitaxel medicine.medical_treatment Polyurethanes 0206 medical engineering Biomedical Engineering Biophysics Breast Neoplasms Bioengineering 02 engineering and technology Pharmacology Biomaterials chemistry.chemical_compound Drug Delivery Systems Drug control Cell Line Tumor medicine Humans Chemotherapy Liposome Chemistry 021001 nanoscience & nanotechnology Antineoplastic Agents Phytogenic 020601 biomedical engineering Controlled release Bioavailability Drug Liberation Liposomes Drug and Narcotic Control Female 0210 nano-technology Drug carrier |
| Zdroj: | Journal of Biomaterials Science, Polymer Edition. 31:2220-2237 |
| ISSN: | 1568-5624 0920-5063 |
| DOI: | 10.1080/09205063.2020.1796230 |
| Popis: | Compared with the traditional chemotherapy by injection, local release of drugs in the lesion area is a more efficient and less harmful treatment for solid tumors. However, the selection of appropriate drug carrier and controlled release of chemotherapy drugs are still great challenges. Herein, a kind of dual-encapsulated three-dimensional (3D) scaffold is designed for local drug release via blending the paclitaxel (PTX) loaded phospholipid liposomes with waterborne polyurethane (PU) by freeze-drying. The controlled release of paclitaxel is carried out through two simultaneous procedures. First, liposomes encapsulated in polyurethane scaffold can slowly release by water absorption and degradation of polyurethane. Then paclitaxel encapsulated in liposomes can also be released into water. Compared with the polyurethane scaffold which directly encapsulated paclitaxel, dual-encapsulated scaffold has slower initial release amount and maintain higher concentration of paclitaxel in later stage. Moreover, the protection of the phospholipid layer can prevent paclitaxel from being quickly decomposed and cleared, which could greatly improve the bioavailability and therapeutic effect of paclitaxel. Cell experiment results can be seen that dual-encapsulated scaffold not only has higher inhibition rate to the breast cancer MCF7 cells, but also has less damage to normal tissue cells. It provides a more effective platform for the local drug therapy in the treatment of tumors.[Formula: see text]. |
| Databáze: | OpenAIRE |
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