Distinctive patterns of pulmonary function change according to baseline lung volume and diffusing capacity
| Autor: | J. Kang, Y-M. Oh, J-H. Lee, E. K. Kim, S. Y. Lim, W. J. Kim, H. I. Yoon, T-H. Kim, T. S. Park, S. O. Kim, S. W. Lee, S-D. Lee, J. S. Lee, null KOLD Study Group |
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| Rok vydání: | 2020 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Pulmonary function testing 03 medical and health sciences 0302 clinical medicine DLCO Internal medicine Diffusing capacity Forced Expiratory Volume Republic of Korea Medicine Humans Lung volumes 030212 general & internal medicine Prospective Studies Prospective cohort study Lung Retrospective Studies COPD business.industry Change patterns Retrospective cohort study respiratory system medicine.disease respiratory tract diseases Infectious Diseases 030228 respiratory system Cardiology Pulmonary Diffusing Capacity business Lung Volume Measurements |
| Zdroj: | The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. 24(6) |
| ISSN: | 1815-7920 |
| Popis: | SETTING: Multicentre retrospective study in South Korea.OBJECTIVE: To longitudinally evaluate changes in lung volume and diffusing capacity for carbon monoxide (DLCO) with forced expiratory volume in 1 sec (FEV1).DESIGN: A total of 155 patients with chronic obstructive pulmonary disease (COPD), whose pulmonary function parameters were measured annually for 5 years, were selected from a prospective cohort in South Korea. A random coefficients model was used to estimate mean annual FEV1, lung volume parameter and DLCO change rates.RESULTS: Patients were classified into four groups based on baseline DLCO and residual volume/total lung capacity (RV/TLC) measurements. The annual FEV1 decline rate was greater in patients with low DLCO than in those with normal DLCO, with the greatest decline occurring in patients with low DLCO and normal RV/TLC. RV and RV/TLC declined in patients with high RV/TLC, whereas these increased in patients with normal RV/TLC. DLCO decreased longitudinally in all four groups, with the greatest decline occurring in patients with normal DLCO and normal RV/TLC.CONCLUSIONS: Different subgroups of patients with COPD exhibited distinctive pulmonary function change patterns. Baseline DLCO and RV/TLC may be used as physiological markers to predict long-term changes in pulmonary function. |
| Databáze: | OpenAIRE |
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