Relation of hyperglycemia to ST-segment resolution after reperfusion for acute myocardial infarction (from Observatoire des Infarctus de Côte-d'Or Survey [RICO])
| Autor: | Yves Cottin, Hamid Makki, Luc Lorgis, Pierre Sicard, Michel Vincent-Martin, Laurent Mock, Marc Freysz, Isabelle L’Huillier, Marianne Zeller, Yves Laurent, Jean-Eric Wolf, Jean-Claude Beer |
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| Rok vydání: | 2005 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Heart disease medicine.medical_treatment Myocardial Infarction Myocardial Reperfusion Coronary Angiography Electrocardiography Internal medicine medicine ST segment Humans cardiovascular diseases Myocardial infarction Aged Retrospective Studies Myocardial reperfusion business.industry Thrombolysis Middle Aged medicine.disease Prognosis Hyperglycemia Cardiology Disease Progression Female Myocardial disease Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | The American journal of cardiology. 98(2) |
| ISSN: | 0002-9149 |
| Popis: | Hyperglycemia has been shown to be a powerful predictor of worse outcome after ST-segment-elevation myocardial infarction (STEMI), which could be related to impaired myocardial reperfusion. This study investigated the association between hyperglycemia and ST-segment resolution (STR) after thrombolysis. From the French regional Observatoire des Infarctus de Côte-d'Or survey, admission glucose in 371 patients with STEMIs who were treated by lysis12 hours was analyzed. The single worst lead electrocardiogram before and 90 minutes after lysis was analyzed, and patients were divided into 3 groups according to the degree of STR: none (30%), partial (30% to 70%), or complete (or=70%). Of the 371 patients, 101 (27.2%) had no STR, 124 (33.4%) had partial STR, and 146 (39.4%) had complete STR. STR decreased with increasing glycemia (p=0.029), and patients with hyperglycemia (glycemiaor=11 mmol/L) were more likely to have no STR. Moreover, hyperglycemia was an independent predictor of incomplete STR even after adjustment for potential confounders (odds ratio 2.348, 95% confidence interval 1.212 to 4.547). In conclusion, the present study suggests a strong association between hyperglycemia and electrocardiographic signs of reperfusion in patients with STEMIs after lysis and suggests the usefulness of evaluating early glycemic control in the setting of reperfusion for acute myocardial infarction. |
| Databáze: | OpenAIRE |
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