The potassium/sodium ratio in the demonstration of sudden ischemic cardiac death: A critical appraisal
| Autor: | Anthony C. Thomas, R.N. Seelye, P.B. Herdson, Lois C. Armiger, M.H. Huymans, M. A. Morrison |
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| Rok vydání: | 1983 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Sodium Potassium Myocardial Infarction Infarction chemistry.chemical_element Sudden death Pathology and Forensic Medicine Sudden cardiac death Death Sudden Dogs Internal medicine medicine Animals Humans Child Aged business.industry Myocardium Nitroblue Tetrazolium Middle Aged medicine.disease Coronary Vessels Staining Coronary arteries medicine.anatomical_structure chemistry Coronary occlusion Anesthesia Cardiology Female business |
| Zdroj: | Pathology. 15:287-296 |
| ISSN: | 0031-3025 |
| DOI: | 10.3109/00313028309083507 |
| Popis: | Summary The practical value of measuring the ratio of potassium ion (K + ) to sodium ion (Na + ) in myocardium as an indicator of early inapparent infarction in sudden cardiac death was assessed using a series of 29 human hearts from selected coroner's autopsies together with experimental material from dogs, including infarcts of 5 min to 4 h duration. Samples for electrolyte analysis were derived from a transverse slice of each heart, taken through both ventricles midway between base and apex, all slices being completely subdivided into a numbered sequence of blocks. Ratios were mapped and compared with macroscopic enzyme staining and histological stains for injured muscle. Detailed examination of coronary arteries was performed on all human cases. Measurement of the K + /Na + ratio did not detect all human cases of proven acute coronary occlusion and did not unequivocally demonstrate experimental infarcts less than 2 h old. Moreover, all ratios fell with increasing duration of autolysis, emphasizing the need for multiple sampling so that each heart may serve as its own control. As a routine test, therefore, the method is both impracticable and unreliable and as previously used has been subject to misinterpretation. |
| Databáze: | OpenAIRE |
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