A prospective clinical trial of tumor hypoxia imaging with 18F-fluoromisonidazole positron emission tomography and computed tomography (F-MISO PET/CT) before and during radiation therapy
| Autor: | Yasumasa Nishimura, Toru Shibata, Makoto Hosono, Shuichi Kanamori, Kiyoshi Nakamatsu, Ryuta Koike, T. Nishikawa, Masaya Tamura, Izumi Tachibana, Kazuki Ishikawa |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male 18F-Fluoromisonidazole medicine.medical_specialty PET/CT Health Toxicology and Mutagenesis medicine.medical_treatment Multimodal Imaging Sensitivity and Specificity Young Adult reoxygenation Fluorodeoxyglucose F18 Uterine cancer Neoplasms 18F-misonidazole Humans Medicine Radiology Nuclear Medicine and imaging Prospective Studies Misonidazole Lung cancer Aged tumor hypoxia Aged 80 and over PET-CT Radiation Tumor hypoxia medicine.diagnostic_test business.industry Reproducibility of Results Middle Aged Prognosis medicine.disease Cell Hypoxia Molecular Imaging Radiation therapy Clinical trial Treatment Outcome Oncology Positron emission tomography Positron-Emission Tomography Female Radiology Radiopharmaceuticals Tomography X-Ray Computed business Nuclear medicine |
| Zdroj: | Journal of Radiation Research |
| ISSN: | 1349-9157 0449-3060 |
| DOI: | 10.1093/jrr/rrt033 |
| Popis: | To visualize intratumoral hypoxic areas and their reoxygenation before and during fractionated radiation therapy (RT), (18)F-fluoromisonidazole positron emission tomography and computed tomography (F-MISO PET/CT) were performed. A total of 10 patients, consisting of four with head and neck cancers, four with gastrointestinal cancers, one with lung cancer, and one with uterine cancer, were included. F-MISO PET/CT was performed twice, before RT and during fractionated RT of approximately 20 Gy/10 fractions, for eight of the 10 patients. F-MISO maximum standardized uptake values (SUVmax) of normal muscles and tumors were measured. The tumor-to-muscle (T/M) ratios of F-MISO SUVmax were also calculated. Mean SUVmax ± standard deviation (SD) of normal muscles was 1.25 ± 0.17, and SUVmax above the mean + 2 SD (≥1.60 SUV) was regarded as a hypoxic area. Nine of the 10 tumors had an F-MISO SUVmax of ≥1.60. All eight tumors examined twice showed a decrease in the SUVmax, T/M ratio, or percentage of hypoxic volume (F-MISO ≥1.60) at approximately 20 Gy, indicating reoxygenation. In conclusion, accumulation of F-MISO of ≥1.60 SUV was regarded as an intratumoral hypoxic area in our F-MISO PET/CT system. Most human tumors (90%) in this small series had hypoxic areas before RT, although hypoxic volume was minimal (0.0-0.3%) for four of the 10 tumors. In addition, reoxygenation was observed in most tumors at two weeks of fractionated RT. |
| Databáze: | OpenAIRE |
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