Estimation of oxidative stress parameters in rats after simultaneous administration of rosuvastatin with antidepressants
| Autor: | Magdalena Izdebska, Mariola Herbet, Iwona Piątkowska-Chmiel, Ewa Jagiełło-Wójtowicz, Ewa Poleszak |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Statin medicine.drug_class Glutathione reductase 030204 cardiovascular system & hematology Pharmacology Citalopram medicine.disease_cause 030226 pharmacology & pharmacy 03 medical and health sciences 0302 clinical medicine medicine Animals Rosuvastatin Rats Wistar Rosuvastatin Calcium Whole blood chemistry.chemical_classification Glutathione Peroxidase Reactive oxygen species business.industry Glutathione peroxidase General Medicine Antidepressive Agents Rats Oxidative Stress Glutathione Reductase chemistry Drug Therapy Combination Hydroxymethylglutaryl-CoA Reductase Inhibitors Reactive Oxygen Species business Oxidation-Reduction Oxidative stress medicine.drug |
| Zdroj: | Pharmacological Reports. 68:172-176 |
| ISSN: | 1734-1140 |
| DOI: | 10.1016/j.pharep.2015.08.004 |
| Popis: | Background Patients commonly receive statin drugs for the primary or secondary prevention of cardiovascular events and also commonly receive antidepressant drugs for the treatment of depression. A many-year polypharmacotherapy can lead to increased side effects of these drugs. It may lead to an oxidation–reduction imbalance and the growth of a generation of reactive oxygen species (ROS) which may induce cellular dysfunctions. Methods The aim of this study was to assess oxidative stress parameters in the blood of rats after simultaneous administration of rosuvastatin (10 mg/kg) with paroxetine (10 mg/kg) or citalopram (10 mg/kg). The activity of glutathione peroxidase (GPX) was determined in whole blood, and the activity of glutathione reductase (GR) and the total antioxidant status (TAS) were determined in the serum. Results The 14-day simultaneous administration of rosuvastatin with paroxetine or citalopram caused an increase in glutathione peroxidase and glutathione reductase activity and did not influence the level of the total antioxidant status. Rosuvastatin (10 mg/kg) or citalopram (10 mg/kg) administered alone to rats for 14 days did not affect the examined parameters. The 14-day application of paroxetine (10 mg/kg) significantly decreased a glutathione peroxidase activity, increased a glutathione reductase activity and did not affect the level of TAS. Conclusions The observed changes may indicate an increased activity of the enzyme system preventing oxidation, which appears to be the effect of the reaction on the severity of oxidative stress during the combined treatment with rosuvastatin and antidepressants. |
| Databáze: | OpenAIRE |
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