HELLP-syndrome as a life-threatening condition: current clinical considerations
| Autor: | A. G. Aslanov, N. V Afanas’yeva, A. M. Kechina, A.N. Strizhakov, I. M. Bogomazova, Sapiyat Ibragimova, Ju. A. Samoylova, E.V. Timokhina, V. S. Belousova |
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| Rok vydání: | 2019 |
| Předmět: |
Embryology
Pregnancy Pediatrics medicine.medical_specialty Proteinuria Thrombotic microangiopathy business.industry HELLP syndrome Incidence (epidemiology) Obstetrics and Gynecology thrombocytopenia Retrospective cohort study Gynecology and obstetrics hellp-syndrome medicine.disease thrombotic microangiopathy Preeclampsia preeclampsia Reproductive Medicine RG1-991 medicine hemolysis medicine.symptom business Complication |
| Zdroj: | Акушерство, гинекология и репродукция, Vol 13, Iss 1, Pp 35-42 (2019) |
| ISSN: | 2500-3194 2313-7347 |
| Popis: | HELLP-syndrome is an extremely serious complication of pregnancy with a high risk of adverse perinatal and maternal outcomes. Aim : to study the clinical course, maternal and perinatal complications in pregnant women with HELLP-syndrome. Materials and methods . We conducted a retrospective study on clinical records of 28 births by women with HELLP-syndrome and 35 women with severe preeclampsia (PE) without HELLP-syndrome manifestations. The diagnostic criteria of the HELLP-syndrome in patients with severe РЕ were based on the symptoms of intravascular hemolysis typically manifested in arterial hypertension, proteinuria, and generalized edema. Results . The classical three symptoms of HELLP-syndrome were noted only in 64.2 % of cases, and the mono-symptomatic course - in 35.7 % of cases. The total triad of HELLP-syndrome (hemolysis, thrombocytopenia, elevation of hepatic enzymes) was recorded in 42.8 % of cases. The most common form was the typical HELLP-syndrome, then - the ELLP-syndrome (elevation of liver enzymes and thrombocytopenia) - 57.2 % of cases; an isolated elevation of hepatic enzymes in severe PE was found in 53.5 % of cases, thrombocytopenia in severe PE - in 64.2 % of cases. A high incidence of adverse perinatal outcomes was also found: premature births (64.2 %) and antenatal fetal death (21.4 %). Conclusion . In the above clinical situations, the diagnostic judgement should be pointed towards the HELLP-syndrome; accordingly, the adequate obstetric management should be initiated to prevent the development of life-threatening complications in both the mother and the fetus. |
| Databáze: | OpenAIRE |
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