Caloric restriction in female reproduction: is it beneficial or detrimental?
| Autor: | Jing Peng, Haibin Kuang, Jiayi Sun, Siying Lu, Hui Liu, Xin Shen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Leptin medicine.medical_specialty lcsh:QH471-489 medicine.medical_treatment Caloric restriction Hypothalamus Ovary Review Biology lcsh:Gynecology and obstetrics Energy homeostasis 03 medical and health sciences Corticotropin-releasing hormone 0302 clinical medicine Endocrinology Internal medicine medicine Animals Humans Insulin lcsh:Reproduction lcsh:RG1-991 Pregnancy 030219 obstetrics & reproductive medicine Energy Reproduction Uterus Obstetrics and Gynecology Undernutrition medicine.disease Neuropeptide Y receptor Ghrelin 030104 developmental biology medicine.anatomical_structure Reproductive Medicine Pituitary Gland Female Developmental Biology |
| Zdroj: | Reproductive Biology and Endocrinology, Vol 19, Iss 1, Pp 1-11 (2021) Reproductive Biology and Endocrinology : RB&E |
| ISSN: | 1477-7827 |
| Popis: | Caloric restriction (CR), an energy-restricted intervention with undernutrition instead of malnutrition, is widely known to prolong lifespan and protect against the age-related deteriorations. Recently it is found that CR significantly affects female reproduction via hypothalamic (corticotropin releasing hormone, neuropeptide Y, agouti-related peptide) and peripheral (leptin, ghrelin, insulin, insulin-like growth factor) mediators, which can regulate the energy homeostasis. Although CR reduces the fertility in female mammals, it exerts positive effects like preserving reproductive capacity. In this review, we aim to discuss the comprehensive effects of CR on the central hypothalamus-pituitary-gonad axis and peripheral ovary and uterus. In addition, we emphasize the influence of CR during pregnancy and highlight the relationship between CR and reproductive-associated diseases. Fully understanding and analyzing the effects of CR on the female reproduction could provide better strategies for the management and prevention of female reproductive dysfunctions. |
| Databáze: | OpenAIRE |
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