Can pretreatment ADC values predict recurrence of bladder cancer after transurethral resection?
| Autor: | Hiroyuki Funatsu, Takeshi Ueda, Akihiro Imamura, Hideyuki Takano, Takashi Uno |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Multivariate analysis Urology Significant negative correlation Sensitivity and Specificity Resection Risk groups Image Interpretation Computer-Assisted medicine Effective diffusion coefficient Humans Radiology Nuclear Medicine and imaging Aged Aged 80 and over Bladder cancer business.industry Reproducibility of Results Retrospective cohort study General Medicine Odds ratio Middle Aged medicine.disease Image Enhancement Surgery body regions Diffusion Magnetic Resonance Imaging Treatment Outcome Urinary Bladder Neoplasms Female Neoplasm Recurrence Local business Algorithms |
| Zdroj: | European journal of radiology. 81(11) |
| ISSN: | 1872-7727 |
| Popis: | Objective The aim of this retrospective study was to investigate the association between the pretreatment apparent diffusion coefficient (ADC) value and recurrence of bladder cancer after transurethral resection. Methods Patients with superficial bladder cancer were identified. Mean ADC values of the tumors were compared between patients with and without recurrence following trans-urethral resection. A receiver–operator characteristic curve was used for determining the optimal cutoff ADC value. Univariate and multivariate analyses were used to determine the effect of ADC values and other factors. Results With a mean follow-up period of 25 months, bladder cancer recurred in 14 of 44 patients (32%). The mean ADC value of tumors in patients with recurrence was lower than in those without recurrence (1.08mm 2 /s vs. 1.28×10 −3 mm 2 /s; p =0.003). The optimal cutoff ADC value for predicting recurrence was determined to be 1.12×10 −3 mm 2 /s. A modest and significant negative correlation was observed between the ADC values and tumor size ( r =−0.436, p =0.008). After adjustment for size and risk groups, an ADC value equal to or less than the optimal cutoff remained a significant predictor of recurrence (odds ratio 6.3, 95% CI 1.23–32.2, p =0.027). Conclusion Pretreatment ADC values may be an independent predictor of bladder cancer recurrence. |
| Databáze: | OpenAIRE |
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