An Alternative Route for Carboni−Lindsey Reaction: N,N Cycloaddition of an Alkene to s-Tetrazine

Autor:	Xiaojian Zhou, Efim G. Kovalev, Vladimir Khodorkovsky, Jacob T. Klug
Rok vydání:	2001
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Tetrazine Chemistry Alkene Product (mathematics) Organic Chemistry Organic chemistry Physical and Theoretical Chemistry Pyrazole Biochemistry Medicinal chemistry Cycloaddition
Zdroj:	Organic Letters. 3:1725-1727
ISSN:	1523-7052 1523-7060
DOI:	10.1021/ol015918p
Popis:	Quantum mechanical calculations show that N,N cycloaddition of alkenes and alkynes to s-tetrazines is possible as an alternative to the well-known C,C cycloaddition (Carboni-Lindsey reaction). Formation of 1,2,4-triazole derivatives (formal product of N,N cycloaddition) along with the pyrazole (formal product of C,C cycloaddition) corroborates this theoretical prediction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::267189c1ff9c4661359654e945a35b01 https://doi.org/10.1021/ol015918p Zobrazit plný text záznamu