Pregnancy-induced alterations in mitochondrial function in euthyroid pregnant women and pregnant women with subclinical hypothyroidism:relation to adverse outcome
| Autor: | Palle Pedersen, Jacob Larsen, Jan Kvetny, Tina Toft Kristensen, Anne-Dorthe Feldthusen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
endocrine system MMP mitochondrial membrane potential endocrine system diseases Endocrinology Diabetes and Metabolism fT4 free thyroxine BMI body mass index TMRM tetramethylrhodamine methyl ester TPOAb thyroid peroxidase antibody carboxy-H2DCFDA 5(6)-carboxy-2'-7'-dichlorodihydrofluoresceindiacetate lcsh:Diseases of the endocrine glands. Clinical endocrinology Pregnancy outcome Preeclampsia Endocrinology ROS reactive oxygen species Thyroid peroxidase Subclinical hypothyroidism Internal medicine medicine Euthyroid Subclinical infection Pregnancy lcsh:RC648-665 Placental abruption biology Obstetrics business.industry tT3 total triiodothyronine Thyroid medicine.disease medicine.anatomical_structure PBMC peripheral blood mononuclear cells biology.protein Gestation Mitochondrial membrane potential business Mitochondrial dysfunction Reactive oxygen species GA gestational age TSH thyroid-stimulating hormone hormones hormone substitutes and hormone antagonists Research Paper |
| Zdroj: | Kvetny, J, Larsen, J, Lyngsie Pedersen, P & Toft Kristensen, T 2014, ' Pregnancy-induced alterations in mitochondrial function in euthyroid pregnant women and pregnant women with subclinical hypothyroidism : relation to adverse outcome ', Journal of Clinical and Translational Endocrinology, vol. 1, no. 1, pp. e13-e17 . https://doi.org/10.1016/j.jcte.2013.12.003 Journal of Clinical & Translational Endocrinology Journal of Clinical & Translational Endocrinology, Vol 1, Iss 1, Pp e13-e17 (2014) |
| DOI: | 10.1016/j.jcte.2013.12.003 |
| Popis: | Background: It is well documented that overt hypothyroidism is associated with adverse pregnancy outcomes, but studies of subclinical hypothyroidism have demonstrated conflicting results. Objective: Thyroid hormones are known to regulate mitochondrial function, and the aim of this study was to examine the possible relationship of subclinical hypothyroidism and mitochondrial dysfunction to adverse pregnancy outcomes in pregnant women. Methods: Women in their third trimester of pregnancy (n = 113) who did not receive thyroid medication were included in this cross-sectional study. All participants were interviewed, and their thyroid status was determined. All participants had concentrations of thyroid hormones (fT 4 and tT 3) within the reference range. In addition to thyroid status, mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) were measured by flow cytometry. To establish a reference range of MMP and ROS, a group of euthyroid, nonpregnant women were used as euthyroid controls. Adverse pregnancy outcome was defined as preterm delivery, preeclampsia, placental abruption, Apgar score |
| Databáze: | OpenAIRE |
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