Documented tuberculin skin testing among infliximab users following a multi-modal risk communication interventions
| Autor: | Jeroan J. Allison, M. Miles Braun, Kenneth G. Saag, Nigel S. B. Rawson, Deborah Shatin, Jeffrey R. Curtis, Larry W. Moreland, Angela Becker, Carolyn K. Martin, Nivedita M. Patkar |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Risk medicine.medical_specialty Tuberculosis Epidemiology Psychological intervention Tuberculin Psoriatic arthritis Internal medicine medicine Humans Pharmacology (medical) skin and connective tissue diseases Adverse effect Tuberculosis Pulmonary Information Dissemination Tuberculin Test Tumor Necrosis Factor-alpha business.industry Antibodies Monoclonal Middle Aged medicine.disease Infliximab Antirheumatic Agents Rheumatoid arthritis Cohort Physical therapy Female business medicine.drug |
| Zdroj: | Pharmacoepidemiology and Drug Safety. 15:11-18 |
| ISSN: | 1099-1557 1053-8569 |
| DOI: | 10.1002/pds.1132 |
| Popis: | Purpose Following its licensure, tuberculosis (TB) was reported as a potential adverse effect of infliximab. Subsequently, the product circular was changed to recommend tuberculin skin testing before patients received infliximab, which was reinforced by several risk communication efforts. The aim of this study was to evaluate patterns and predictors of documented tuberculin skin testing in patients before and after manufacturer, federal, and academic risk communications. Methods Patients administered infliximab were identified from 11 health plans located throughout the United States, and claims data were examined to determine whether the patients had received a tuberculin skin test. Patients were divided into three cohorts depending on the timing of their first infliximab treatment in relation to the risk communication efforts. Results The overall tuberculin skin testing rate doubled from 15.4% in the first cohort to 30.9% in the last cohort, while the rate of pre-infliximab treatment testing increased from 0 to 27.7% (Chi-squared test for trend, p |
| Databáze: | OpenAIRE |
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