Theoretical and Experimental Investigations on Inclusion Complex β-Cyclodextrin and Sulcatone: A Cardiovascular Activity Evaluation
| Autor: | Samuel A. A. de Sousa, Ana Maria S. Costa, Ivan Saraiva Silva, Márcio E. P. Santos, Aldeídia Pereira de Oliveira, Francisco I. da Silva, Márcio dos Santos Rocha, Francisco das Chagas Alves Lima, Raiane M. Silva, Eduardo Lima Feitosa, Péricles Barreto Alves, Sidney Gonçalo de Lima |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Diffraction hypotension Thermogravimetric analysis Materials science Cyclodextrin Infrared sulcatone General Chemistry computational methods symbols.namesake Differential scanning calorimetry Fourier transform chemistry β-cyclodextrin symbols vasorelaxant activity Molecule Physical chemistry Fourier transform infrared spectroscopy |
| Zdroj: | Journal of the Brazilian Chemical Society, Volume: 31, Issue: 5, Pages: 1064-1077, Published: 30 APR 2020 Journal of the Brazilian Chemical Society v.31 n.5 2020 Journal of the Brazilian Chemical Society Sociedade Brasileira de Química (SBQ) instacron:SBQ |
| ISSN: | 0103-5053 |
| Popis: | In this paper, we have applied state-of-the-art technologies and new investigations were developed focusing on obtaining simple and inexpensive molecules for treating cardiovascular diseases, as they are considered the leading cause of death in the world. For the first time, the inclusion complex of sulcatone (SU) and β-cyclodextrin (β-CD) was achieved (using a spray drier) and characterized making use of spectroscopic, thermal and computational methods. In addition, the system was evaluated regarding its vasorelaxant properties. Evidence of the inclusion complex formation was provided using different techniques, such as X-ray diffraction (XRD), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), Fourier transform infrared (FTIR), and 1H nuclear magnetic resonance (NMR) spectroscopies and then deduced by pharmacological experiments, which showed significant changes in relation to the initial material. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|