Different strategies for mechanical VENTilation during CardioPulmonary Bypass (CPBVENT 2014): study protocol for a randomized controlled trial
| Autor: | Sabino Scolletta, Stefano Romagnoli, Roberta Meroni, E Maglioni, Vincenzo Pota, Marcello Guarnieri, Cinzia Trumello, Antonio Scognamiglio, Ottavio Alfieri, Alessandro Maria Budillon, Alberto Zangrillo, Francesco Saglietti, Gianluca Paternoster, Stefano De Paulis, Elena Bignami |
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| Přispěvatelé: | Bignami, Elena, Guarnieri, Marcello, Saglietti, Francesco, Maglioni, Enivarco Massimo, Scolletta, Sabino, Romagnoli, Stefano, De Paulis, Stefano, Paternoster, Gianluca, Trumello, Cinzia, Meroni, Roberta, Scognamiglio, Antonio, Budillon, Alessandro Maria, Pota, Vincenzo, Zangrillo, Alberto, Alfieri, Ottavio, Bignami, E., Guarnieri, M., Saglietti, F., Maglioni, E. M., Scolletta, S., Romagnoli, S., De Paulis, S., Paternoster, G., Trumello, C., Meroni, R., Scognamiglio, A., Budillon, A. M., Pota, V., Zangrillo, A., Alfieri, O. |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Time Factors
medicine.medical_treatment Medicine (miscellaneous) 030204 cardiovascular system & hematology law.invention Pulmonary function testing Study Protocol 0302 clinical medicine Postoperative Complications Randomized controlled trial Clinical Protocols law Risk Factors Clinical endpoint Cardiac Surgical Procedure Pharmacology (medical) Single-Blind Method Continuous positive airway pressure Lung lcsh:R5-920 Cardiopulmonary Bypass Postoperative pulmonary complications Cardiopulmonary bypass CPAP Low tidal volume Protective ventilation Respiratory insufficiency Systemic inflammatory response Intensive care unit Cardiac surgery Treatment Outcome Italy Research Design Anesthesia lcsh:Medicine (General) Human medicine.medical_specialty Time Factor Cardiopulmonary bypa 03 medical and health sciences medicine Humans Cardiac Surgical Procedures Clinical Protocol Mechanical ventilation Respiratory Mechanic business.industry Risk Factor Respiration Artificial 030228 respiratory system Respiratory Mechanics Postoperative Complication business Postoperative pulmonary complication |
| Zdroj: | Trials Trials, Vol 18, Iss 1, Pp 1-10 (2017) |
| ISSN: | 1745-6215 |
| Popis: | Background There is no consensus on which lung-protective strategies should be used in cardiac surgery patients. Sparse and small randomized clinical and animal trials suggest that maintaining mechanical ventilation during cardiopulmonary bypass is protective on the lungs. Unfortunately, such evidence is weak as it comes from surrogate and minor clinical endpoints mainly limited to elective coronary surgery. According to the available data in the academic literature, an unquestionable standardized strategy of lung protection during cardiopulmonary bypass cannot be recommended. The purpose of the CPBVENT study is to investigate the effectiveness of different strategies of mechanical ventilation during cardiopulmonary bypass on postoperative pulmonary function and complications. Methods/design The CPBVENT study is a single-blind, multicenter, randomized controlled trial. We are going to enroll 870 patients undergoing elective cardiac surgery with planned use of cardiopulmonary bypass. Patients will be randomized into three groups: (1) no mechanical ventilation during cardiopulmonary bypass, (2) continuous positive airway pressure of 5 cmH2O during cardiopulmonary bypass, (3) respiratory rate of 5 acts/min with a tidal volume of 2–3 ml/Kg of ideal body weight and positive end-expiratory pressure of 3–5 cmH2O during cardiopulmonary bypass. The primary endpoint will be the incidence of a PaO2/FiO2 ratio |
| Databáze: | OpenAIRE |
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