| Autor: |
Tefera Worku Mekonnen, Haile Fentahun Darge, Hsieh-Chih Tsai, Yihenew Simegniew Birhan, Endiries Yibru Hanurry, Hailemichael Tegenu Gebrie, Hsiao-Ying Chou, Juin-Yih Lai, Shinn-Zong Lin, Horng-Jyh Harn, Yu-Shuan Chen |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Colloids and Surfaces B: Biointerfaces. 213:112391 |
| ISSN: |
0927-7765 |
| DOI: |
10.1016/j.colsurfb.2022.112391 |
| Popis: |
Enhancement of drug efficacy is essential in cancer treatment. The immune stimulator ovalbumin (Ova)-coated citric acid (AC-)-stabilized iron oxide nanoparticles (AC-IO-Ova NPs) and enhanced permeability and retention (EPR)-based tumor targeted 4.5 generation poly(amidoamine) dendrimer(4.5GDP)-cisplatin (Cis-pt) nanocomplex (NC) (4.5GDP-Cis-pt NC) were used for enhanced anticancer efficiency. The formations of 4.5GDP-Cis-pt NC, AC-IO, and AC-IO-Ova NPs were examined via FTIR spectroscopy, X-ray diffraction, Raman spectroscopy, and X-ray photoelectron spectroscopy. The conjugation of Cis-pt with 4.5GDP was confirmed using carbon NMR spectroscopy. The tumor-specific 4.5GDP-Cis-pt NC provided 45%and 28% cumulative cisplatin release in 72 h at pH 6.5 and 7.4, respectively. A significant immune response with high TNF-α and IL-6 cytokine secretion was confirmed for the co-incubation of AC-IO-Ova with RAW 264.7 or HaCaT cells. AC-IO-Ova NPs were biocompatible with different cell lines, even at a high concentration (200 µg mL |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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